目的 比较新型冠状病毒肺炎(COVID-19)疫情不同阶段病原学检测策略及检测结果变化,对疫情防控工作提供技术支持。方法 将六安市2020年1月20日至2月20日新冠肺炎疫情分为三个阶段,在不同阶段采集不同对象的咽拭子标本,共采集4 088份标本,采用实时荧光RT-PCR检测新型冠状病毒核酸,比较不同阶段不同检测对象核酸检出率。结果 2020年1月20日至2月20日,六安市共检测咽拭子标本4 088份,其中疑似病例标本492份,重点人群标本3 596份。共检出69份COVID-19确诊患者,10例无症状感染者,阳性检出率为1.93%。疑似病例阳性检出率(14.0%)高于重点人群阳性检出率(0.4%)(χ2=398.166,P＜0.05)。第一阶段疑似病人阳性检出率(25.8%)与第二阶段疑似病人阳性检出率(20.8%)差异不具有统计学意义(χ2=0.735,P＞0.05)。第二阶段疑似病人阳性检出率(20.8%)大于第三阶段(3.7%)(χ2=28.775,P＜0.05)。第二阶段重点人群阳性检出率为0.9%,高于第三阶段(0.2%)(χ2=9.954,P＜0.05)。结论 六安市根据不同阶段疫情形势所采取的检测策略,使疫情受到了较好的控制,但应当继续保持防控措施,加强对发热病人、返乡返岗人员、入境人员以及医护人员和外卖快递人员等一些可能起到高传播作用的特殊人群的筛查。
Abstract
Objective To compare COVID-19 epidemic detection strategies and test results at different stages,and provide technical support for epidemic prevention and control. Methods The COVID-19 epidemic in Lu'an from January 20,2020 to February 20th was divided into three stages.Different throat swabs samples were collected from different stages.4088 samples were collected and real-time coronal fluorescence RT-PCR was used to detect new coronavirus nucleic acids. Results From January 20 to February 20,2020,4088 throat swab samples were detected in Lu'an City,including 492 suspected cases and 3596 key population samples.69 cases of covid-19 were diagnosed and 10 cases of asymptomatic infection were detected.The positive rate was 1.93%.The positive detection rate of suspected cases (14.0%) was higher than that of key population (0.4%) (χ2=398.166,P＜0.05).The positive detection rate of suspected patients in the first stage (25.8%) was not significantly different from that in the second stage (20.8%) (χ2=0.735,P＞0.05).The positive rate of suspected patients in the second stage (20.8%) was higher than that in the third stage (3.7%) (χ2=28.775,P＜ 0.05).The positive rate of the second stage was 0.9%,higher than that of the third stage (0.2%) (χ2=9.954,P＜ 0.05). Conclusion Lu'an City adopted the detection strategy according to the epidemic situation in different stages,so that the epidemic situation has been better controlled.Prevention and control measures should be maintained,and strengthen the screening of fever patients,returnees,entry personnel,medical staff and delivery personnel who may play a high transmission role.
关键词
新型冠状病毒 /
病原学检测 /
策略
Key words
COVID-19 /
Etiological detection /
Strategy
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