目的 分析实验室检测在学校结核病疫情处置中的作用,为丰富学校结核病疫情防控手段提供依据。方法 按《学校结核病防控工作规范》,对某学校结核病患者的密切接触者和一般接触人群进行结核病筛查,采集相关标本进行实验室检测。结果 该学校共发现5例结核病患者。密切接触者和一般接触者共160人进行了筛查和实验室检测,PPD试验强阳性15人,强阳率9.38%。5例确诊的患者中,有4例为病原学阳性,1例涂阳,3例培养阳性,4例患者阳性标本分子生物学阳性。结论 学校是结核病疫情高发场所,实验室病原学检测在发现传染源中发挥着重要作用,应重视新诊断技术在检测过程中的应用。
Abstract
Objective To analyze the role of laboratory test in the investigation and analysis of tuberculosis(TB) epidemics in schools,and to provide evidence for enriching the prevention and control measures of tuberculosis in schools. Methods According to the "Code of Practice for Prevention and Control of School Tuberculosis",TB screening was conducted for close contacts and general contacts of TB patients in a school,and relevant specimens were collected for laboratory testing. Results In this school,5 cases of tuberculosis were found.A total of 160 close contacts and general contacts were screened and tested in the laboratory.PPD test was highly positive in 15 people,with a strong positive rate of 9.38%.Of the 5 confirmed patients,4 were positive for etiology,1 was smear-positive,3 were positive for culture,and 4 were positive for molecular biology. Conclusion School is a high-risk place for tuberculosis epidemic.Laboratory pathogen detection plays an important role in the discovery of infectious sources.It is necessary to pay attention to the application of new diagnostic techniques in the detection process.
关键词
学校 /
肺结核 /
聚集性疫情 /
实验室检测
Key words
School /
Tuberculosis /
Cluster epidemic /
Laboratory testing
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参考文献
[1] World Health Organization.Global tuberculosis report 2017.Geneva: World Health Organization,2018.
[2] 王焕珍,常建华,李朋娟.一起学校结核病聚集性疫情流行病学调查[J].中国学校卫生,2015,36(4):618-619.
[3] 王莉丽.合肥市学校结核病聚集性疫情控制措施及效果分析[J].中国学校卫生,2017,38(12):1818-1820,1824.
[4] 国家卫生计生委办公厅,教育部办公厅.学校结核病防控工作规范[Z].2018.
[5] 中华人民共和国国家卫生和计划生育委员会.肺结核诊断[J].传染病信息.2017,30(6):1-12.
[6] 陈伟,陈秋兰,夏愔愔,等.2008~2012年全国学生结核病疫情特征分析[J].中国防痨杂志,2013,35(12):949-954.
[7] 国务院办公厅.十三五全国结核病防治规划[Z].2017.
[8] 赵平,余琴,张喻,等.GeneXpert MTB/RIF技术对肺结核的诊断效能评估[J].检验医学与临床,2018,15(8):1159-1162.
[9] 张志,罗保斌,刘东艳,等.结核分枝杆菌基因分型技术研究进展[J].河北北方学院学报(自然科学版),2016,32(6):58-60.
[10] 李广法.浅谈学校肺结核疫情特点及防控措施[J].安徽预防医学杂志,2014,20(1):39-40.
[11] 李金方,黄敏,张晖,等.一起学校肺结核聚集性疫情的调查与分析[J].江苏预防医学,2018,29(4):417-418.
基金
安徽省卫计委课题(No 15tb011);安徽省胸科医院课题(No xk2015010)