目的 分析云浮市2015—2019年疑似预防接种异常反应(AEFI)的发生特征和AEFI监测系统运转情况。方法 通过全国AEFI信息管理系统收集云浮市2015—2019年报告的个案数据,采用描述性流行病学方法分析AEFI发生情况。结果 云浮市2015—2019年共报告AEFI个案578例,报告发生率8.69/10万剂次。主要发生在5—8月份,共281例,占报告总数的48.62%;年龄以0岁组为主,共217例,占37.54%。90.83%的AEFI病例发生在接种疫苗后24 h内 。除2015年48 h内报告率、调查表及时报告率和2016年48 h内报告率不达标,其余各年份各指标均达到国家AEFI监测方案的要求。一般反应359例,占62.11%;异常反应192例,占33.22%。报告病例数涉及的的疫苗主要是无细胞百白破联合疫苗(DTaP)、麻疹-风疹联合减毒活疫苗(MR)和流行性乙型脑炎减毒活疫苗(JEV-L);99.48%的病例预后良好。结论 云浮市AEFI监测工作运行良好,预防接种安全。

Objective To analyze the occurrence characteristics of AEFI and the operation of AEFI monitoring system in Yunfu City from 2015 to 2019. Methods The case data of Yunfu City from 2015 to 2019 were collected through the national AEFI information management system,and the occurrence of AEFI was analyzed by descriptive epidemiological method. Results A total of 578 cases of AEFI were reported in Yunfu City from 2015 to 2019(the reported incidence was 8.69/100000 doses).A total of 281 cases (48.62%) mainly occurred from May to August,and 217 cases (37.54%) mainly occurred in 0-year-old group. 90.83% of AEFI cases occurred within 24 hours after vaccination. Except that the reporting rate within 48 hours in 2015,the timely reporting rate of questionnaire and the reporting rate within 48 hours in 2016 were not up to the standard,all indicators in other years met the requirements of the national AEFI monitoring program.There were 359 general reactions (62.11%) and 192 abnormal reactions (33.22%).The vaccines involved in the number of reported cases were mainly acellular DPT combined vaccine (DTaP),measles rubella combined live attenuated vaccine (MR) and Japanese encephalitis live attenuated vaccine (jev-l).99.48% of the cases had good prognosis. Conclusion The monitoring of AEFI in Yunfu City works well and the safety of vaccination is good.