目的 观察芜湖市乙肝免疫球蛋白(HBIG)与乙肝疫苗(HepB)联合免疫阻断乙型肝炎病毒传播效果。方法 收集芜湖市2017年4月至2019年12月319例乙型肝炎病毒表面抗原(HBsAg)阳性孕产妇所生婴儿血清, 所有婴儿在分娩后24 h内均注射100国际单位(IU)HBIG,并按照“0-1-6”接种程序完成3剂次乙肝疫苗接种,在完成第3剂次乙肝疫苗接种后1～6个月,即儿童7月龄至12月龄期间召回检测“乙肝两对半”,评估免疫效果。结果 婴儿HBsAg阴性率98.43%;婴儿HBsAb阳性率98.12%,母亲HBeAg阳性组与阴性组的婴儿HBsAg阴性率差异均有统计学意义(Fisher’确切概率P=0.005);婴儿HBsAb阳性率差异有统计学意义(χ2校正=6.079,P=0.014)。结论 HBIG与HepB联合免疫阻断乙肝病毒母婴传播效果显著。
Abstract
Objective To observe the effect of hepatitis B immunoglobulin (HBIG) combined with hepatitis B vaccine (HepB) on blocking the transmission of hepatitis B virus in Wuhu City. Methods Infant Serum samples from 319 pregnant women with positive hepatitis B virus surface antigen (HBsAg) were collected from April 2017 to December 2019 in Wuhu City.All infants were injected with 100 international units (IU) HBIG in 24h after delivery,and 3 doses of hepatitis B vaccine were received according to the "0-1-6" vaccination procedure.During the 1~6 months after the completion of the third dose of hepatitis B vaccination,that is,when children were 7 month old to 12 month old,they would be recalled to detect hepatitis B to evaluate the immune effect. Results The negative rate of HBsAg in infants was 98.43%,and the positive rate of HBsAb in infants was 98.12%.There was significant difference in the negative rate of HBsAg in infants between the mother's HBeAg positive group and the negative group (Fisher’ exact probability P=0.005).There was significant difference in the positive rate of HBsAb in infants. Conclusion The combined immunization of HBIG and HepB has a significant effect in blocking mother-to-child transmission of hepatitis B.
关键词
乙肝免疫球蛋白 /
乙肝疫苗 /
乙肝病毒 /
母婴阻断传播 /
预防接种 /
免疫效果评估
Key words
Hepatitis B immunoglobulin /
Hepatitis B vaccine /
Hepatitis B virus /
Mother-to-child transmission interruption /
Immune effect evaluation
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基金
2017年安徽省妇幼健康科研课题(编号:7FY008)
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