目的 了解开封市健康人群流行性脑脊髓膜炎(简称流脑)A群和C群IgG抗体水平,为流脑防控工作提供依据。方法 采用随机分层抽样的方法,抽取2019—2020年开封市罗王乡和大李庄乡＜1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、≥20岁7个年龄组共1 003名健康人群作为研究对象。采用酶联免疫吸附试验检测研究对象血清流脑A群和C群IgG抗体水平。结果 开封市健康人群血清A群、C群IgG流脑抗体阳性率分别为49.85 %和54.84 %。不同年龄组A群流脑抗体阳性率(χ2=162.674,P＜0.001)和C群流脑抗体阳性率(χ2=140.422, P＜0.001)差异有统计学意义,＜1岁组A群和C群IgG抗体阳性率均为最低,A群IgG抗体阳性率≥20岁组最高,C群IgG抗体阳性率3～4岁组最高。有免疫史的人群阳性率高于无免疫史及免疫史不详人群,接种年限在1年左右,抗体阳性率较高。结论 开封市健康人群血清A群和C群IgG流脑抗体水平较低,特别是＜1岁组人群,应加强流脑疫苗接种,提高流脑疫苗接种覆盖率,提升人群流脑抗体水平。
Abstract
Objective To investigate the level of IgG antibody in serogroup A and C of epidemic cerebrospinal meningitis among healthy population in Kaifeng City,and to provide theoretical basis for prevention and control of epidemic cerebrospinal meningitis. Methods A total of 1003 subjects in 7 age groups,including <1 year,1-2 years,3-4 years,5-6 years,7-14 years,15-19 years and ≥ 20 years in Luowang Township and Dalizhuang Township of Kaifeng City from 2019 to 2020 were selected as study subjects using a random stratified sampling method.Enzyme-linked immunosorbent assay was used to detect the IgG antibody levels in serogroupp A and serogroup C of epidemic cerebrospinal meningitisserum. Results The positive rate of meningococcal serogroup A and C IgG in healthy population in Kaifeng City were 49.85% and 54.84%,respectively.The positive rate of meningococcal serogroup A (χ2=162.674,p＜0.001) and C (χ2=140.422,P＜0.001) were significantly different in different age groups.The positive rate of meningococcal serogroup A and C IgG antibody positivity rates were both the lowest in the <1 year old group.The IgG positive rate of serogroup A was highest in the≥20 age group.The IgG positive rate of serogroup C was highest in the 3～4 age group.Positive rate was higher in people with immunization history than in people without immunization history and people with unknown immunization history.The antibody positivity rate was higher when the vaccination period is about one year. Conclusion In Kaifeng,the serum IgG antibody levels of meningococcal serogroup A and C are relatively low in healthy population,especially in the<1 year old group.Hence,the vaccination of meningococcal vaccine should be enhanced to improve the coverage rate of meningococcal vaccine and raise the antibody level of epidemic cerebrospinal meningitis in the population.
关键词
流行性脑脊髓膜炎 /
抗体水平 /
健康人群
Key words
Epidemic cerebrospinal meningitis /
Antibody level /
Healthy population
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