目的 了解合肥市手足口病(HFMD)流行特征及病原学特征,为有效预防和控制HFMD提供科学依据。方法 通过中国疾病预防控制信息系统收集合肥市2019—2022年HFMD病例资料,采用SPSS 28.0进行统计学分析。结果 2019—2022年合肥市报告HFMD病例44 044例,年均报告发病率为121.64/10万,重症率为0.03%,无死亡病例。全年各月均有病例报告,发病时间主要集中在5—8月,男性报告病例多于女性,男女性别比1.40∶1。发病年龄主要集中在0~5岁(χ2=439.299,P<0.001),职业构成以散居儿童为主(χ2=183.784,P<0.001)。肠道病毒核酸阳性检出率为40.60%,主要病原为CVA6型,其次为CVA16型。结论 合肥市HFMD报告发病率总体呈下降趋势,主要流行株为CVA6型。
Abstract
Objective To understand the epidemiological and etiological characteristics of hand-foot-mouth disease (HFMD) in Hefei City,and to provide scientific basis for effective prevention and control of HFMD. Methods Data of HFMD in Hefei City from 2019 to 2022 were collected from China Disease Prevention and Control Information System.SPSS 28.0 was used for statistical analysis. Results A total of 44 044 HFMD cases were reported in Hefei City from 2019 to 2022,with an average annual reported incidence of 121.64/100 000.The rate of severe disease was 0.03% and there were no fatal cases.The HFMD had been reported in all months of the year,mainly concentrated in May to August.Males reported more cases than females,with a gender ratio of 1.40∶1.The age of onset was mainly concentrated between 0-5 years old (χ2=439.299,P<0.001),and the occupational composition was dominated by scattered children (χ2=183.784,P<0.001).The positive detection rate of enterovirus nucleic acid was 40.60%,with the main pathogen being CVA6 type,followed by CVA16 type. Conclusion The reported incidence rate of HFMD in Hefei City shows a general downward trend,and the main epidemic strain is CVA6.
关键词
手足口病 /
病毒 /
流行特征
Key words
Hand-foot-mouth disease /
Virus /
Epidemiological feature
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] 胡海贇,蔡明毅,葛玮.2016—2019年手足口病病原体流行病学特征分析[J].中华实验和临床病毒学杂志,2021,35(3):291-295.
[2] Zhu P,Ji W,Li D,et al.Current status of hand-foot-and-mouth disease[J].J Biomed Sci,2023,30(1):15.
[3] 宋飏,刘艳晓,张瑜,等.中国手足口病时空分异特征及影响因素[J].地理学报,2022,77(3):574-588.
[4] 陈意灯.小儿手足口病的预防和控制对策研究[J].保健文汇,2021,22(12):184-185.
[5] 陈红,王欢,向仁强,等.绵阳市涪城区2009—2019手足口病流行病学特征及病原学检测分析[J].医学动物防制,2021,37(12):1174-1176+1180.
[6] 中华人民共和国卫生部.手足口病诊疗指南(2010版)[J].中国实用乡村医生杂志,2012,19(19):9-11.
[7] 叶文,欧新华,肖姗,等.2014—2019年长沙市手足口病病原谱及流行病学特征分析[J].中国病毒病杂志,2022,12(2):133-137.
[8] 刘纭江.环境对手足口病流行状况影响[J].全科口腔医学电子杂志,2019,6(20):22.
[9] 张静.2008—2017年中国手足口病流行趋势和病原变化动态数列分析[J].中华流行病学杂志,2019,40(2):147-154.
[10] 张涛.2010—2016年枣庄市手足口病流行病学与病原学特征分析[J].现代预防医学,2018,45(19):3475-3479.
[11] 马婉婉,吴家兵,孙良,等.阜阳市2008—2016年手足口病流行病学及病原学特征分析[J].安徽医科大学学报,2018,53(12):1898-1902.
[12] Puenpa J,Suwannakarn K,Chansaenroj J,et al.Genetic diversity and evolution of enterovirus A71 subgenogroup C1 from children with hand,foot,and mouth disease in Thailand[J].Arch Virol,2021,166(8):2209-2216.
[13] 戴映雪,岳勇,岳丽梅,等.成都市不同年龄幼托儿童手足口病影响因素分析[J].中国学校卫生,2020,41(8):1204-1207+1211.
[14] 孟浩蓉,赵庆龙,黄飙,等.广东省、安徽省和吉林省体感温度与手足口病发病的关系及其空间异质性分析[J].中华流行病学杂志,2021,42(3):520-526.
[15] 宫晨,韩姗珊,邓革红,等.2016—2021年广西壮族自治区手足口病流行特征及时空聚集性分析[J].疾病监测,2022,37(11):1436-1441.
[16] Ooi MH,Wong SC,Clear D,et al.Adenovirus type 21-associated acute flaccid paralysis during an outbreak of hand-foot-and-mouth disease in Sarawak,Malaysia[J].Clin Infect Dis,2003,36(5):550-559.
[17] 鲍金圭,李崇建,江慧,等.2016—2018年钦州市手足口病住院患儿病原学检测结果分析[J].检验医学与临床,2019,16(24):3592-3595.
[18] 黄威,陈雨,罗恺炜,等.湖南省2008—2017年手足口病病原学与流行特征分析[J].中华实验和临床病毒学杂志,2019,33(1):16-20.
PDF(827 KB)
