纳米二氧化硅致肺损伤作用的研究进展

周思凡; 朱启星

doi:10.19837/j.cnki.ahyf.2024.04.010

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安徽预防医学杂志 ›› 2024, Vol. 30 ›› Issue (4) : 305-308. DOI: 10.19837/j.cnki.ahyf.2024.04.010

综述

纳米二氧化硅致肺损伤作用的研究进展

周思凡, 朱启星

作者信息 +

Research progress of silica nanoparticles effects on lung-injurious

ZHOU Sifan, ZHU Qixing

Author information +

文章历史 +

摘要

纳米二氧化硅(SiNPs)被广泛用于农业生产、生物医药和建筑建材等领域,人群暴露的风险逐渐增加。研究表明,SiNPs会导致肺损伤,对其他脏器也存在潜在毒性,但其毒性机制尚未完全阐明。本文围绕SiNPs的特征、暴露环境和呼吸道暴露SiNPs致肺损伤的毒性机制进行综述。

Abstract

With the widespread use of silica nanoparticles (SiNPs) in agriculture,biomedicine and building materials,the risk of its population exposure are increasing.Many studies have shown that SiNPs could cause lung damage and are potentially toxic to other organs.However,the mechanisms of its toxicity has not been fully elucidated.The present review summarizes the characteristics of SiNPs and its environmental exposure and illustrates the toxicity mechanism of lung injury caused by respiratory exposure of SiNPs.

导出引用

周思凡, 朱启星. 纳米二氧化硅致肺损伤作用的研究进展[J]. 安徽预防医学杂志. 2024, 30(4): 305-308 https://doi.org/10.19837/j.cnki.ahyf.2024.04.010

ZHOU Sifan, ZHU Qixing. Research progress of silica nanoparticles effects on lung-injurious[J]. Anhui Journal of Preventive Medicine. 2024, 30(4): 305-308 https://doi.org/10.19837/j.cnki.ahyf.2024.04.010

中图分类号： R563

参考文献

[1] Marques Da Silva V,Benjdir M,Montagne P,et al.Pulmonary toxicity of silica linked to its micro- or nanometric particle size and crystal structure:a review[J].Nanomaterials(Basel),2022,12(14):2392.
[2] 李涵,国海东.介孔二氧化硅纳米颗粒及其承载药物在心肌保护中的应用[J].中国组织化学与细胞化学杂志,2020,29(5):478-482.
[3] 杨灵娟.纳米二氧化硅在涂料中的应用研究[J].决策探索(中),2020(8):95-96.
[4] World Health Organization.WHO guidelines on protecting workers from potential risks of manufactured nanomaterials[EB/OL].(2017-02-02)[2023-08-25].https://www.who.int/publications/i/item/9789241550048.
[5] Bajpai VK,Kamle M,Shukla S,et al.Prospects of using nanotechnology for food preservation,safety,and security[J].J Food Drug Anal,2018,26(4):1201-1214.
[6] Huang Y,Li P,Zhao R,et al.Silica nanoparticles:biomedical applications and toxicity[J].Biomed Pharmacother,2022,151:113053.
[7] Yong T,Zhang X,Bie N,et al.Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy[J].Nat Commun,2019,10(1):3838.
[8] 张晓雪,王路遥,李宁,等.纳米二氧化硅对职业接触人群健康影响[J].中国职业医学,2018,45(4):530-533.
[9] 张晓雪,王路遥,李宁,等.纳米二氧化硅对职业接触人群肺功能的影响研究[C]// 2018环境与健康学术会议——精准环境健康:跨学科合作的挑战论文汇编.沈阳,2018:157-158.
[10] 王静,李延明,刘涛,等.纳米颗粒肺部健康效应及职业危害研究进展[J].工业卫生与职业病,2022,48(1):83-86.
[11] 周思凡,王周健,高磊,等.补体片段C3a及其受体在纳米二氧化硅致肺损伤中水平变化[J].环境与职业医学,2023,40(8):877-883.
[12] Murugadoss S,Lison D,Godderis L,et al.Toxicology of silica nanoparticles:an update[J].Arch Toxicol,2017,91(9):2967-3010.
[13] Xie G,Sun J,Zhong G,et al.Biodistribution and toxicity of intravenously administered silica nanoparticles in mice[J].Arch Toxicol,2010,84(3):183-190.
[14] 刘雨凡,王继,郭彩霞,等.纳米二氧化硅的心血管系统毒性及其作用机制的研究进展[J].吉林大学学报(医学版),2021,47(4):1043-1049.
[15] Sharma VK,Filip J,Zboril R,et al.Natural inorganic nanoparticles–formation,fate,and toxicity in the environment[J].Chem Soc Rev,2015,44(23):8410-8423.
[16] Yin H,Li J,Tian J,et al.Uterine pyruvate metabolic disorder induced by silica nanoparticles act through the pentose phosphate pathway[J].J Hazard Mater,2021,412:125234.
[17] Seaton A.Silicosis[J].Occup Med (Lond),2023,73(3):170.
[18] Detampel P,Ganguly A,Tehranian S,et al.In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells[J].PLoS One,2019,14(9):e0223339.
[19] Wang Y,Kalinina A,Sun T,et al.Probabilistic modeling of the flows and environmental risks of nano-silica[J].Sci Total Environ,2016,545/546:67-76.
[20] Tian L,Dai S,Wang J,et al.Nanoquartz in Late Permian C1 coal and the high incidence of female lung cancer in the Pearl River Origin area:a retrospective cohort study[J].BMC Public Health,2008,8:398.
[21] Park EJ,Kang MS,Jin SW,et al.Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles[J].Nanotoxicology,2021,15(8):1087-1101.
[22] Li Y,Duan J,Chai X,et al.Microarray-assisted size-effect study of amorphous silica nanoparticles on human bronchial epithelial cells[J].Nanoscale,2019,11(47):22907-22923.
[23] Liu X,Wei W,Liu Z,et al.Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage[J].Proc Natl Acad Sci USA,2021,118(44):e2108131118.
[24] Yu Y,Pan Y,Chang B,et al.Silica nanoparticles induce pulmonary damage in rats via VEGFC/D-VEGFR3 signaling-mediated lymphangiogenesis and remodeling[J].Toxicology,2023,493:153552.
[25] Bao L,Geng Z,Wang J,et al.Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice[J].Environ Res,2022,213:113678.
[26] Ren L,Liu J,Zhang J,et al.Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells[J].Environ Pollut,2019,255(Pt 1):113172.
[27] Yang M,Jing L,Wang J,et al.Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation[J].Int J Nanomedicine,2016,11:6217-6228.
[28] Sonin DL,Korolev DV,Postnov VN,et al.Silicon-containing nanocarriers for targeted drug delivery:synthesis,physicochemical properties and acute toxicity[J].Drug Deliv,2016,23(5):1747-1756.
[29] Hassankhani R,Esmaeillou M,Tehrani AA,et al.In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice[J].Environ Sci Pollut Res Int,2015,22(2):1127-1132.
[30] Nabeshi H,Yoshikawa T,Matsuyama K,et al.Systemic distribution,nuclear entry and cytotoxicity of amorphous nanosilica following topical application[J].Biomaterials,2011,32(11):2713-2724.
[31] Mohammadpour R,Yazdimamaghani M,Cheney DL,et al.Subchronic toxicity of silica nanoparticles as a function of size and porosity[J].J Control Release,2019,304:216-232.
[32] 高玮,易静.活性氧在T淋巴细胞中的作用[J].中国细胞生物学学报,2018,40(10):1787-1792.
[33] Xia T,Kovochich M,Brant J,et al.Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm[J].Nano Lett,2006,6(8):1794-1807.
[34] Yang X,Yang P,Zhang J,et al.Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway[J].Environ Toxicol,2022,37(9):2291-2301.
[35] Xie D,Zhou Y,Luo X.Amorphous silica nanoparticles induce tumorigenesis via regulating ATP5H/SOD1-related oxidative stress,oxidative phosphorylation and EIF4G2/PABPC1-associated translational initiation[J].PeerJ,2019,7:e6455.
[36] Liu Y,Wei H,Tang J,et al.Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation[J].Chemosphere,2020,255:126954.
[37] Coll RC,Schroder K,Pelegrín P.NLRP3 and pyroptosis blockers for treating inflammatory diseases[J].Trends Pharmacol Sci,2022,43(8):653-668.
[38] Ma L,Han Z,Yin H,et al.Characterization of cathepsin B in mediating silica nanoparticle-induced macrophage pyroptosis via an NLRP3-dependent manner[J].J Inflamm Res,2022,15:4537-4545.
[39] Tan Y,Yu D,Feng J,et al.Toxicity evaluation of silica nanoparticles for delivery applications[J].Drug Deliv Transl Res,2023,13(9):2213-2238.
[40] Maser E,Schulz M,Sauer UG,et al.In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials[J].Mutat Res Genet Toxicol Environ Mutagen,2015,794:57-74.
[41] Nemmar A,Yuvaraju P,Beegam S,et al.Oxidative stress,inflammation,and DNA damage in multiple organs of mice acutely exposed to amorphous silica nanoparticles[J].Int J Nanomedicine,2016,11:919-928.
[42] Zhao X,Abulikemu A,Lv S,et al.Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective[J].Chemosphere,2021,275:129969.
[43] Li Y,Zhu Y,Zhao B,et al.Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling[J].Nanotoxicology,2022,16(6/7/8):713-732.
[44] Zhu Y,Zhang Y,Fan Z,et al.Silica nanoparticles trigger chaperone HSPB8-assisted selective autophagy via TFEB activation in hepatocytes[J].Small,2023,19(5):e2204310.
[45] Liu X,Tu B,Jiang X,et al.Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles[J].Life Sci,2019,233:116741.
[46] Wang M,Li J,Dong S,et al.Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction[J].Part Fibre Toxicol,2020,17(1):23.
[47] Zhao X,Wei S,Li Z,et al.Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis[J].Cell Death Dis,2019,10(2):127.
[48] Law PP,Holland ML.DNA methylation at the crossroads of gene and environment interactions[J].Essays Biochem,2019,63(6):717-726.
[49] Zou Y,Li Q,Jiang L,et al.DNA hypermethylation of CREB3L1 and bcl-2 associated with the mitochondrial-mediated apoptosis via PI3K/akt pathway in human BEAS-2B cells exposure to silica nanoparticles[J].PLoS One,2016,11(6):e0158475.
[50] Lamouille S,Xu J,Derynck R.Molecular mechanisms of epithelial-mesenchymal transition[J].Nat Rev Mol Cell Biol,2014,15(3):178-196.
[51] Zhou S,Wang Z,Gao L,et al.C5a/C5aR1 axis as a key driver promotes epithelial-to-mesenchymal transition in airway epithelial cells in silica nanoparticles-induced pulmonary fibrosis[J].Int Immunopharmacol,2023,125(Pt B):111112.
[52] Guo C,You DY,Li H,et al.Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1α (SDF-1α)[J].J Int Med Res,2019,47(3):1264-1278.
[53] Boccuni F,Ferrante R,Tombolini F,et al.Occupational exposure to graphene and silica nanoparticles.Part I:workplace measurements and samplings[J].Nanotoxicology,2020,14(9):1280-1300.
[54] Liang S,Duan J,Hu H,et al.Comprehensive analysis of SiNPs on the genome-wide transcriptional changes in Caenorhabditis elegans[J].Int J Nanomedicine,2020,15:5227-5237.