目的 对武汉市蔡甸区报告的2例发热伴血小板减少综合征(SFTS)确诊病例进行流行病学调查,分析传播原因,为SFTS防控提供依据。方法 对蔡甸区2024年6—7月报告的2例SFTS确诊病例及风险人员进行流行病学调查,采集病例及其密切接触者血清进行大别班达病毒核酸检测。结果 2例SFTS确诊病例均为农民,大别班达病毒核酸检测为阳性,有野外暴露史和动物接触史,其中病例1蜱叮咬史不详,病例2有蜱虫叮咬史。临床表现及转归显示:2例SFTS确诊病例均有发热伴血小板减少症状,病例1死亡,病例2痊愈。密切接触者调查显示,病例1有3名密切接触者,大别班达病毒核酸均阴性,病例2有1名密切接触者,大别班达病毒核酸阳性,病例2及其密切接触者在同一个潜伏期内大别班达病毒核酸阳性,有共同的有野外暴露史和动物接触史。结论 SFTS确诊病例被蜱虫叮咬发病的可能性大,田间(野外)活动史是大别班达病毒感染的风险因素。

Objective To conduct an epidemiological investigation on two confirmed cases of severe fever with thrombocytopenia syndrome (SFTS) reported in Caidian District of Wuhan,to analyze the causes of transmission,and provide basis for the prevention and control of SFTS. Methods An epidemiological investigation was conducted on two confirmed cases of SFTS and individuals at risk reported in Caidian District from June 2024 to July 2024.Serum samples from the cases and their close contacts were collected for nucleic acid testing of Bandavirus dabieense. Results Both two confirmed cases of SFTS were farmers,with positive Bandavirus dabieense nucleic acid tests,history of outdoor exposure,and animal contact.The tick bite history of case 1 was unknown,while case 2 had a history of tick bites.The clinical manifestations and outcomes showed that both two cases had symptoms of fever and thrombocytopenia,case 1 died,and case 2 recovered.The close contact investigation revealed that case 1 had three close contacts,all negative for Bandavirus dabieense nucleic acid.Case 2 had one close contact,and positive for Bandavirus dabieense nucleic acid.Both case 2 and the close contact tested positive for Bandavirus dabieense nucleic acid within the same incubation period,and shared histories of outdoor exposure and animal contact. Conclusion SFTS-confirmed cases have a high likelihood of developing disease from tick bites,and a history of field (outdoor) activities is a risk factor for Bandavirus dabieense infection.