目的 了解贵州省六盘水市2019—2023年人间布鲁氏菌病（简称布病）流行特征，为布病的预防控制提供科学依据。方法 运用描述性流行病学方法对2019—2023年六盘水市人间布病病例的流行特征进行分析。结果 2019—2023年六盘水市人间布病发病率分别为0.27/10万、0.20/10万、0.46/10万、0.89/10万、0.86/10万，呈上升趋势（χ {}_{趋势}^2=18.983，P<0.001），共报告人间布病81例。报告病例以男性为主，占69.14%（56/81）；发病年龄以40~<65岁为主，占65.43%（53/81）；职业以农民为主，占64.20%（52/81）；地区分布以盘州市为主，占69.14%（56/81）。布病病例临床症状以发热、肌肉关节痛和乏力为主，分别占81.48%（66/81）、76.54%（62/81）、60.49%（49/81）；病例发病至诊断时间间隔为10（4，20） d，不同年份发病至诊断时间间隔差异无统计学意义（H=4.060，P=0.398）；病例感染可能主要来源于羊，有羊接触史者占79.01%（64/81）。结论 六盘水市人间布病发病呈上升趋势，发病年龄以40~<65岁为主，发病人群以男性和接触羊的养殖人员为主，盘州市报告病例较多。

Objective To understand the epidemiological characteristics of human brucellosis in Liupanshui of Guizhou Province from 2019 to 2023, and to provide scientific basis for the prevention and control of brucellosis. Methods Descriptive epidemiological methods were used to analyze the epidemiological characteristics of human brucellosis cases in Liupanshui from 2019 to 2023. Results From 2019 to 2023,the incidence rates of human brucellosis in Liupanshui were 0.27/100 000, 0.20/100 000, 0.46/100 000, 0.89/100 000 and 0.86/100 000, respectively, showed an upward trend (χ {}_{trend}^2=18.983, P<0.001), and a total of 81 cases of human brucellosis were reported. The reported cases were mainly male, accounting for 69.14% (56/81), and the age of onset was mainly 40-<65 years old, accounting for 65.43% (53/81). The occupation was mainly farmers, accounting for 64.20% (52/81), and the regional distribution was mainly in Panzhou, accounting for 69.14% (56/81). The clinical symptoms of brucellosis cases were mainly fever, muscle and joint pain, and fatigue, accounting for 81.48% (66/81), 76.54% (62/81), and 60.49% (49/81), respectively. The time interval from the onset to diagnosis was 10 (4, 20) days. There was no statistically significant difference in the time interval from the onset to diagnosis among different years (H=4.060, P=0.398). The infection of the cases might mainly originate from sheep, and 79.01% (64/81) of them had a history of contact with sheep. Conclusion The incidence of human brucellosis in Liupanshui is on the rise, with the age of onset is mainly 40-<65 years old. The affected population is mainly male and mainly sheep farmers who have contact with sheep. A relatively large number of cases have been reported in Panzhou.