目的 观察固定剂量复合剂治疗肺结核的效果及其不良反应。方法 2014～2016年绩溪县结核病防治门诊发现的初治肺结核病人给予国家免费提供的抗结核固定剂量复合剂(FDC)治疗,并监测治疗前、中、后肝肾功能、血常规、痰涂片、胸片的变化及不良反应。结果 经采用抗结核固定剂量复合剂治疗,肺结核涂阳病人痰菌阴转率达100.00%,治愈率达95.92%,涂阴病人完成疗程率达97.25%,胸片病灶总有效吸收率93.04%,不良反应发生率55.69%。结论 使用固定剂量复合剂治疗肺结核病患者,治疗效果明显,而且具有很好的治疗依从性。

Objective To observe the effect and adverse reaction of fixed dose compound preparation in the treatment of pulmonary tuberculosis. Methods From 2014 to 2016, pulmonary tuberculosis patients found at the TB control clinic of Jixi county received national free anti tuberculosis fixed dose combination (FDC) treatment, and the changes of liver and kidney function, blood routine, sputum smear and chest X-ray before and after treatment were observed. Results After standard anti tuberculosis treatment, the sputum negative conversion rate of smear positive pulmonary tuberculosis patients was 100%, the cure rate was up to 95.92%, the treatment rate of smear negative patients was up to 97.25%, the total effective rate of chest lesions was 93.04%, and adverse reaction rate was 55.69%. Conclusion The treatment effect of using fixed dose combination therapy for patients with pulmonary tuberculosis is obvious, and has good treatment compliance.