目的 探讨阴道B超引导下卵泡穿刺联合人工授精治疗排卵障碍性不孕(AI)患者的临床效果。方法 选取2015年1月～2017年1月本院收治的排卵障碍性不孕患者57例作为研究对象并进行随机分为观察组(28例)和对照组(29例),观察组促排后采用阴道B超引导下卵泡穿刺联合人工授精治疗,对照组采用促排后宫腔内人工授精治疗。比较两组患者促排卵周期、排卵率、流产率及临床妊娠率。结果 观察组28例患者共34个促排卵周期,对照组29例患者共41个促排卵周期,观察组平均促排卵周期(1.21±0.15个)显著少于对照组(1.41±0.23个),差异具有统计学意义(t=3.048,P＜0.05);观察组排卵率100%(34/34)、生化妊娠率44.12%(15/34)、流产率13.33%(2/15)、临床妊娠率38.24%(13/34)分别与对照组的70.73%(29/41)、21.95%(9/41)、22.22%(2/9)、17.07%(7/41)比较,差异具有统计学意义(χ2值依次为2.809、3.857、3.346、4.269,P值均＜0.05);观察组患者卵巢过度刺激综合征发生率8.82%(3/34)以及多胎发生率15.38%(2/13)均分别低于对照组12.20%(5/41)、28.57%(2/7),差异具有统计学意义(χ2值依次为2.943、3.625,P值均＜0.05)。结论 阴道B超引导下卵泡穿刺联合人工授精治疗AI促排卵周期相对较少,可明显提高临床妊娠率并降低卵巢过度刺激综合征发生率。
Abstract
Objective To discuss the clinical effect analysis of transvaginal ultrasound guided follicular puncture combined with artificial insemination in the treatment of anovulatory infertility. Methods 57 cases of Anovulatory infertility patients in our hospital from Jan 2015 to Jan 2017 were selected as the research objects and randomly divided into the observation group (28 cases) treated with transvaginal ultrasound guided follicular puncture combined with artificial insemination, and the control group (29 cases) treated only by intrauterine insemination. Recorded and compared the superovulation cycle, ovulation rate, abortion rate and clinical pregnancy rate. Results In this study, the superovulation cycle of 28 patients in the observation group was 34, the superovulation cycle of 29 patients in the control group was 41, the average superovulation cycles of the observation group (1.21±0.15) was significantly less than the control group (1.41±0.23), the difference was statistically significant (t=3.048,P＜0.05); The ovulation rate,biochemical pregnancy rate,abortion rate and clinical pregnancy rate of the observation group were significantly higher than the control group,the difference was statistically significant (the values of χ2 were 2.809,3.857,3.346, 4.269 respectively,all P<0.05); The incidence of ovarian hyperstimulation syndrome(OHS) and the incidence of multiple births of the observation group were significantly lower than the control group,the difference was statistically significant (the values of χ2 were 2.943, 3.625 respectively,all P<0.05). Conclusion The superovulation cycle of transvaginal ultrasound guided follicular puncture combined with artificial insemination is relatively less, can significantly improve the clinical pregnancy rate and reduce the incidence of OHS.
关键词
B超 /
卵泡穿刺 /
丈夫精人工授精 /
排卵障碍性不孕 /
临床妊娠
Key words
B ultrasound /
Follicular puncture /
Artificial insemination by husband /
Clinical pregnancy
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