目的 分析多重耐药菌耐药性,为抗菌药物的临床合理应用提供依据。方法 2018年在阜阳市人民医院不同临床科室采集19 198份生物学标本,对标本进行细菌分离培养,获取菌株后,对其进行药敏试验。结果 2018年采集的19 198份标本,分离获得5 605株病原菌,其中1 456株菌出现多重耐药,多重耐药菌检出率25.98%。主要耐药菌株为大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌、金黄色葡萄球菌、铜绿假单胞菌。从痰液中检出多重耐药菌占50.07%。大肠埃希菌对头孢曲松、左氧氟沙星、复方新诺明的耐药率超过73.00%,肺炎克雷伯菌对头孢曲松的耐药率高达95.25%,金黄色葡萄球菌对苯唑西林、青霉素耐药率超过80%。结论 多重耐药菌对常规使用的抗生素耐药率较高,增加了临床治疗难度,应加强耐药菌的监测,合理使用抗生素。

Objective To analyze the drug resistance of multidrug-resistant organisms (MDROs) and to provide basis for the rational clinical application of antibiotics. Methods 19 198 biological specimens were collected from different clinical departments of Fuyang People's Hospital in 2018. The specimens were isolated and cultured,and the strains were obtained and tested for drug susceptibility. Results 19 198 samples were collected in 2018 and 5605 strains of pathogenic bacteria were isolated,of which 1456 strains showed multidrug resistant,and the detection rate of multidrug-resistant organisms was 25.98%. The main resistant strains were Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,Staphylococcus aureus and Pseudomonas aeruginosa. Multidrug-resistant organisms were detected from sputum accounted for 50.07%. The drug resistance rate of Escherichia coli to ceftriaxone,levofloxacin and compound sulfamethoxazole was over 73.00%,Klebsiella pneumoniae to ceftriaxone was as high as 95.25%,and Staphylococcus aureus to oxacillin and penicillin was over 80%. Conclusion The high resistance rate of multidrug-resistant organisms to conventional antibiotics increased the difficulty of clinical treatment. It’s necessary to strengthen the monitoring of drug-resistant organisms and rational use of antibiotics.