目的 了解系统性红斑狼疮(Systemic lupus erythematosus,SLE)患者睡眠障碍发生情况及其可能的影响因素,对改善SLE患者睡眠质量,提高SLE患者生活质量提供理论依据。方法 采用问答式问卷调查方法,通过匹兹堡睡眠质量量表调查安徽医科大学第一附属医院住院部和门诊的158例SLE患者睡眠质量情况,计算匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Inventory,PSQI)。结果 共调查158例SLE患者,其中有睡眠障碍的患者102例(64.6%),不同疾病活动度的SLE患者睡眠障碍的发生率不同(χ2=5.688,P=0.017)。是否患关节炎(χ2=5.712,P=0.017)和狼疮肾炎(χ2=6.305,P=0.012)的SLE患者出现睡眠障碍不同。此外,不同疾病活动度(P=0.002)、是否有狼疮肾炎(P=0.044)、是否有关节炎(P<0.001)、是否初诊(P=0.022)的SLE患者PSQI存在统计学差异。结论 SLE患者睡眠质量差,存在明显睡眠障碍。
Abstract
Objective To understand the occurrence rate and influencing factors of sleep disorders in systemic lupus erythematosus (SLE) patients,and to provide some theoretical basis for improving sleep quality and life quality of SLE patients. Methods The sleep quality of 158 SLE patients in the inpatient department and outpatient department of the First Affiliated Hospital of Anhui Medical University was investigated by the Pittsburgh Sleep Quality Inventory (PSQI). Results A total of 158 SLE patients were investigated.102 (64.6%) patients had sleep disorders.The prevalence of sleep disorders was different among SLE patients with different disease activity (χ2=5.688,P=0.017).The prevalence rate of sleep disorders was also different in SLE patients with different disease characteristics,especially those with arthritis (χ2=5.712,P=0.017) and lupus nephritis (χ2=6.305,P=0.012).In addition,different disease activity (P=0.002),with or without lupus nephritis (P= 0.044),with or without arthritis (P<0.001),and whether initial diagnosis (P=0.022) had significant effects on sleep disorders (PSQI) in SLE patients. Conclusion SLE patients have poor sleep quality and sleep disorders.
关键词
系统性红斑狼疮 /
睡眠障碍 /
横断面调查
Key words
Systemic lupus erythematosus /
Sleep disorders /
Influencing factors
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基金
国家级大学生创新创业训练计划项目(201810366055);安徽医科大学博士科研经费(XJ201619);国家自然科学基金(81803310)。
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