目的 分析宿州市2014-2019年疑似预防接种异常反应信息管理系统(AEFIMS)数据,对全市疑似预防接种异常反应(AEFI)监测运转质量和监测数据进行分析评价。方法 通过AEFIMS收集2014年1月1日-2019年12月31日宿州市AEFIMS所有报告的个案数据,运用描述流行病学方法分析。结果 2014-2019年宿州市AEFIMS共收到2 898例AEFI个案,所辖四县一区均上报AEFI,48 h内AEFI报告率为100%;在276例需调查的AEFI中,48 h内AEFI调查率为98.90%;3 d内AEFI调查表报告率为98.19%; AEFI分类率为100%。全市估算报告发生率23.92/10万剂,呈现逐年增加,其中预防接种异常反应为2.12/10万剂,严重AEFI为0.23/10万剂;男女比例为1.31:1,AEFI以小年龄儿童为主,≤1岁占75.94%;夏季报告例数最多(42.68%),春季次之(22.43%),冬季最低(16.29%);反应多发生于预防接种后的1 d内,一般反应以发热、局部红肿、硬结为主;异常反应常见的为过敏性皮疹、荨麻疹、斑丘疹、血管性水肿和热性惊厥。结论 宿州市AEFIMS运行良好,AEFI监测敏感性和质量稳步推进,无疫苗接种事故和疫苗质量事故报告,预防接种异常反应估算报告发生率均在预期范围内。

Objective To analyze the data of suspected vaccination adverse reaction information management system (AEFIMS) in Suzhou City from 2014 to 2019,and analyze and evaluate the operation quality and monitoring data of AEFI. Methods Data of all cases reported by AEFIMS in Suzhou City from January 1,2014 to December 31,2019 were collected and analyzed by descriptive epidemiological method. Results A total of 2 898 cases were received from AEFIMS in Suzhou City from 2014 to 2019.All the four counties and one district under its jurisdiction reported AEFI,and the reporting rate of AEFI within 48 h was 100%; among 276 AEFI cases to be investigated,the investigation rate of AEFI within 48 h was 98.90%.The reporting rate of AEFI questionnaire within 3d was 98.19%.The classification rate of AEFI was 100%.The estimated reported incidence rate of the city was 23.92/100 000 doses,showing an increase year by year,including 2.12/100 000 doses of adverse reactions to vaccination and 0.23/100 000 doses of severe AEFI.The ratio of male to female was 1.31:1.AEFI was dominated by children under 1 year old,accounting for 75.94%.The number of reported cases in summer was the most (42.68%),followed by spring (22.43%),and the lowest in winter (16.29%) days,the general reactions were fever,local redness and induration.The common abnormal reactions were allergic rash,urticaria,maculopapular,vascular edema and febrile convulsion. Conclusion The AEFIMS is running well in Suzhou City,and the monitoring sensitivity and quality of AEFI are advancing steadily.There are no reports of vaccination accidents and vaccine quality accidents.The estimated incidence of adverse reactions to vaccination is within the expected range.