目的 分析血浆中表皮生长因子受体3(ErbB3)蛋白表达水平与超重的相关性,探讨ErbB3在超重中的作用。方法 招募2019 年7-8月于弋矶山医院体检中心的128名33~79岁成年人,按体质量指数(BMI)≥24.0 Kg/m2 为超重组,BMI<24.0 Kg/m2为对照组,采集研究对象血液样本,使用酶联免疫吸附法(ELISA) 检测血浆ErbB3蛋白。结果 男性研究对象,超重组血浆ErbB3蛋白水平低于对照组;饮酒人群中,超重组ErbB3蛋白水平也明显降低,差异均具有统计学意义(P＜0.05)。ErbB3水平在男性(r=-0.252,P=0.034)、饮酒人群(r=-0.389,P =0.008)中与BMI呈负相关。结论 ErbB3水平降低与成人超重相关,但仅限于男性和饮酒的人群。
Abstract
Objective To analyze the correlation between the expression of epidermal growth factor receptor 3 (ErbB3) protein in plasma and overweight,and to explore the role of ErbB3 in overweight. Methods 128 adults aged 33-79 were recruited from the physical examination center of Yijishan hospital from July to August in 2019. Body mass index (BMI) ≥24.0 Kg/m2 was used as overweight,and BMI<24.0 Kg/m2 was used as control. Plasma ErbB3 level was assessed by the Enzyme-linked immunosorbent assay (ELISA). Results In the male population,the plasma ErbB3 level in overweight group was lower than that in the control group. In the drinking population,the level of ErbB3 in overweight population was also significantly reduced,and the difference was statistically significant(P<0.05). The level of ErbB3 was negatively correlated with BMI in males(r = -0.252,P= 0.034)and drinking population(r=-0.389,P=0.008). Conclusion In males and drinkers,the decrease of ErbB3 level is associated with adult overweight.
关键词
ErbB3 /
表皮生长因子受体 /
超重 /
肥胖
Key words
ErbB3 /
Epidermal growth factor receptor /
Overweight /
Obesity
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基金
安徽省教育厅高校自然科学研究重点项目(KJ2019A0405:KJ2019A0404);国家卫生健康委员会卫生经济与政策研究重点实验室开放课题(NHC-HEPR2019001); 安徽省重点研究与开发计划(1804h08020261);安徽省自然科学基金项目(1808085QH283)
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