目的 分析周口市百日咳报告发病水平,评价免疫预防效果及疫情反弹的风险。方法 通过河南省免疫规划信息管理系统、中国疾病预防控制信息系统收集2005-2019年周口市百白破疫苗报告接种率和百日咳报告发病数据,抽取健康人群750份血清标本,检测百日咳血清抗体水平。结果 2005-2019年,周口市适龄儿童百白破疫苗全程四剂次平均接种率94.47%,百日咳平均报告发病率0.17/10万,2019年健康人群百日咳抗体阳性率12.27%。结论 周口市2005-2019年百白破疫苗全程接种率较高且接种水平比较稳定,百日咳报告发病率相对较低,健康人群中百日咳抗体水平较低,周口市存在百日咳疫情再现的风险。
Abstract
Objective To analyze the reported incidence level of pertussis in Zhoukou City and evaluate the effect of immune prevention and the risk of epidemic rebound. Methods The data of DPT vaccine coverage rate and reported incidence of pertussis in Zhoukou City from 2005 to 2019 were collected through Henan Provincial Immunization Planning Information Management System and China Disease Control and prevention information System. A total of 750 serum samples of healthy people were collected to detect the serum antibody level of pertussis. Results During the 2005-2019 years,the average vaccination rate of four doses of DPT vaccine in Zhoukou was 94.47%,the average incidence rate of pertussis was 0.17/10 million,and the positive rate of pertussis antibody among healthy people in 2019 was 12.27%. Conclusion In Zhoukou,the total vaccination rate of DPT vaccine in 2005-2019 years was higher and the vaccination level was relatively stable. The incidence rate of pertussis was relatively low,and the level of pertussis antibody in healthy population was relatively low. Zhoukou had the risk of recurrence of pertussis.
关键词
百日咳 /
发病率 /
疫苗接种 /
抗体水平 /
免疫预防
Key words
Pertussis /
Incidence rate /
Vaccination rate /
Antibody level /
Immune effect
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] StanleyA.Plotkin,Walter A.Orenstein,Paul A.Offit.疫苗学[M].第5版,北京:人民卫生出版社,2011.10:511.
[2] 王增国,马超锋,闫永平.全球百日咳重现及中国百日咳相关研究现状[J].中国疫苗和免疫,2016,22(3):345-349.
[3] Octavia S,Sintchenko V,Gwendolyn L.Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008-2010.[J].Infect Dis,2012,205(8):1220-1224.
[4] CDC.Pertussis epidemic-Washiongton,2012[J].MMWR,2012,61(28):517-522.
[5] Miyaji Y,Otsuka N,Toyoizumi-Ajisaka H,et al.Genetic analysis of Bordetella pertussis isolates from the 2008-2010pertussis epidemic in Japan[J].PLoS One,2013,8(10):e77165.
[6] Kim SH,Lee J,Sung HY,et al.Recent trends of antigenic variation in Bordetella pertussis isolates in Korea[J].JKMS,2014,29(3):328-333.
[7] 高志刚,黄海涛,刘勇,等.天津市百日咳发病反弹及流行病学特征改变的影响因素分析[J].中国疫苗和免疫,2011,17(3):212-215.
[8] 宁桂军,吴丹,李军宏,等.全球2010~2014年白喉、破伤风和百日咳免疫预防和发病水平现况分析[J].中国疫苗和免疫,2016,22(2):159-164.
[9] 王传清,朱启镕.百日咳与非百日咳迁延性慢性咳嗽儿童及青少年临床特征分析[J].临床儿科杂志.2010,28(6):542-544.
[10] 李晓梅,张铁钢,曾阳,等.北京市2012年常住人口百日咳抗体水平调查[J].中国疫苗和免疫,2014,20(6):542-546.
[11] 王涛,王海红,易文娟,等.2017年北京市昌平区健康人群百日咳、白喉、破伤风抗体水平监测[J].实用预防医学,2019,26(5):593-596.
[12] 刘倩,丰达星,赵升,等.河南省健康人群百日咳、白喉、破伤风抗体水平分析[J].当代医学,2013,19(31):160-161.
[13] 李虹,杨婷婷,陈霄,等.2016—2017年山西省健康人群百日咳抗体水平监测[J].实用医技杂志,2019,26(10):1282-1283.
[14] 李怡秋,喻文雅,闫玉英.石家庄市健康人群百日咳抗体水平分析[J].现代预防医学,2015,42(23):4377-4378,4391.
[15] 肖梦晴.百日咳疫苗改善疾病进程[J].国际生物制品学杂志,2018,4(1):39.
[16] Mcglrr A,Fisman DN. Duration ofpertussis immunity after DTaP immunization:a meta-analysis[J]. Pediatrics,2015,135(2): 331-343.
PDF(987 KB)
