目的 了解滁州市艾滋病抗病毒治疗现状,探析艾滋病抗病毒治疗效果改进措施。方法 选取滁州市2018年在治的HIV感染者和艾滋病病人(HIV/AIDS)362例,对其进行CD4⁺T淋巴细胞计数、HIV病毒载量检测和基因型耐药检测,分析HIV/AIDS免疫学和病毒学指标变化情况,评估抗病毒治疗效果。结果 359例HIV/AIDS接受了HIV病毒载量检测,333例病毒载量小于1 000 cps/ml,病毒抑制率92.7%。362例HIV/AIDS病例治疗后和治疗前CD4⁺T淋巴计数差异有统计学意义(Z=-11.759,P＜0.001);治疗后不同病毒载量组的CD4⁺T淋巴细胞计数差异有统计学意义(F=18.453,P＜0.001),其中＜50 cps/ml组与50~1 000 cps/ml组CD4⁺T淋巴细胞计数明显大于基线值(Z=-11.441,P＜0.001;Z=-3.65,P＜0.001)。26例HIV/AIDS病例病毒载量＞1 000 cp/ml,8例耐药,耐药率为2.2%(8/359)。结论 HIV/AIDS病例抗病毒治疗,有助于改善患者细胞免疫水平。

Objective To understand the current situation of AIDS antiviral therapy in Chuzhou City,and to explore measures to improve the effect of AIDS antiviral therapy. Methods A total of 362 patients with HIV/AIDS in Chuzhou City in 2018 were selected.CD4⁺T lymphocyte count,HIV viral load and genotypic drug resistance were detected.The changes of immunological and virological indexes of HIV/AIDS were analyzed to evaluate the effect of antiviral therapy. Results A total of 359 cases of HIV/AIDS received HIV viral load test,333 cases of viral load less than 1 000 cps/ml,the virus inhibition rate was 92.7%.In 362 cases,there was significant difference in CD4⁺T lymphocyte count of HIV / AIDS after treatment and before treatment (Z=-11.759,P＜ 0.001).After treatment,the CD4⁺T lymphocyte count of different viral load groups was significantly different (F=18.453,P＜0.001),and the CD4⁺T lymphocyte count of viral load ＜50cps/ml group and 50-1 000 cps/ml group were significantly higher than baseline value (Z=-11.441,P＜0.001;Z=-3.65,P＜0.001).A total of 26 cases of HIV/AIDS viral load>1 000 cps/ml,8 cases had drug resistance,and the drug resistance rate was 2.2% (8/359). Conclusion Antiviral therapy for HIV / AIDS cases is helpful to improve the cellular immune level of patients.