抗精神病药致心源性猝死机制及临床预防

田英汉; 夏磊; 杨铖; 刘乐伟; 刘寰忠

doi:10.19837/j.cnki.ahyf.2022.05.002

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安徽预防医学杂志 ›› 2022, Vol. 28 ›› Issue (5) : 352-356. DOI: 10.19837/j.cnki.ahyf.2022.05.002

专家约稿

抗精神病药致心源性猝死机制及临床预防

田英汉, 夏磊, 杨铖, 刘乐伟, 刘寰忠

作者信息 +

Mechanism and clinical prevention of sudden cardiac death caused by antipsychotics

TIAN Ying-han, XIA Lei, YANG Cheng, LIU Le-wei, LIU Huan-zhong

Author information +

文章历史 +

摘要

抗精神病药是目前治疗精神分裂症以及其他精神病性障碍患者的主要手段,而使用抗精神病药会导致患者心源性猝死(sudden cardiac death,SCD)风险显著增加,其发病率约是未服药患者的2倍。熟悉SCD的发生机制和风险因素,有利于临床医生早期识别和干预SCD,从而改善接受抗精神病药治疗患者的远期预后。本文就抗精神病药致SCD风险、发生机制以及SCD临床预防的相关研究进行综述。

Abstract

Antipsychotics are currently the mainstay of treatment for patients with schizophrenia as well as other psychotic disorders,but the use of antipsychotics can lead to a significantly increased risk of sudden cardiac death (SCD),which is approximately twice as common in patients not taking medication.Familiarity with the mechanisms and risk factors of SCD will help clinicians to identify and intervene in SCD early,thereby improving the long-term prognosis of patients receiving antipsychotic medication.This article reviews studies related to the risk of SCD from antipsychotics,the mechanisms of occurrence,and clinical prevention of SCD.

导出引用

田英汉, 夏磊, 杨铖, 刘乐伟, 刘寰忠. 抗精神病药致心源性猝死机制及临床预防[J]. 安徽预防医学杂志. 2022, 28(5): 352-356 https://doi.org/10.19837/j.cnki.ahyf.2022.05.002

TIAN Ying-han, XIA Lei, YANG Cheng, LIU Le-wei, LIU Huan-zhong. Mechanism and clinical prevention of sudden cardiac death caused by antipsychotics[J]. Anhui Journal of Preventive Medicine. 2022, 28(5): 352-356 https://doi.org/10.19837/j.cnki.ahyf.2022.05.002

中图分类号： R749

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