目的 探索淮河流域重点地区胃癌患者的危险因素,为淮河流域胃癌的一级防控提供依据。方法 从当地区(县)肿瘤登记系统选取确诊时间在2020年1月1日—2021年7月31日期间肿瘤诊断ICD-10编码为C16的胃癌新发病例作为病例组,按照1∶2的配对原则选择与患者同地区、同性别、无既往恶性肿瘤病史、年龄±5岁的人群作为对照组,对两组人群进行问卷调查和身体测量,共纳入胃癌病例240例,对照480例。采用SAS统计软件进行logistic回归分析胃癌发生的危险因素。结果 多因素logistic回归分析结果显示,饮食口味偏咸(OR=2.161,95%CI:1.141~4.095)、喜食辛辣食物(OR=1.773,95%CI:1.057~2.975)、接触二手烟(OR=1.963,95%CI:1.168~3.299)、经常爱生气(OR=8.704,95%CI:3.582~21.147)和消化系统疾病史(OR=2.302,95%CI:1.329~3.988)是胃癌发生的危险因素;BMI(OR=0.697,95%CI:0.639~0.761)、文化程度高(OR=0.454,95%CI:0.248~0.830)和每日饮水量≥1 500 mL(OR=0.443,95%CI:0.217~0.906)与胃癌的发生呈负相关。结论 胃癌的发病与饮食习惯、二手烟暴露、性格情绪特征以及消化系统疾病史等因素有关。应进一步加强人群癌症防控意识,开展健康教育和行为指导,控制癌症危险因素,降低胃癌的发病风险。
Abstract
Objective To explore the risk factors of gastric cancer patients in key areas of the Huaihe River Basin,and to provide a basis for the primary prevention and control of gastric cancer in the Huaihe River Basin. Methods New cases of gastric cancer with a tumor diagnosis ICD-10 code of C16 between January 1,2020 and July 31,2021 were selected from the local regional (county) cancer registry system as the case group.In the same region,same gender,no previous history of malignancy,and age ±5 years were selected as the control group according to the 1:2 matching principle.Questionnaires and body measurements were administered to both groups.A total of 240 gastric cancer cases and 480 control cases were included.Risk factors of gastric cancer were analyzed by logistic regression using SAS. Results The results of multivariate logistic regression analysis showed that salty taste in diet (OR=2.161,95%CI:1.141-4.095),preference for spicy food (OR=1.773,95%CI:1.057-2.975),exposure to second-hand smoke (OR=1.963,95%CI:1.168-3.299),frequent anger (OR=8.704,95%CI:3.582-21.147) and history of digestive disorders (OR=2.302,95%CI:1.329-3.988) were risk factors for the development of gastric cancer.However,BMI (OR=0.697,95%CI:0.639-0.761),high literacy (OR=0.454,95%CI:0.248-0.830) and daily water intake ≥1 500 mL (OR=0.443,95%CI: 0.217-0.906) were negatively associated with the occurrence of gastric cancer. Conclusion The development of gastric cancer is associated with dietary habits,second-hand smoke exposure,personality and emotional characteristics,and history of digestive system diseases.Awareness of cancer prevention and control among the population,health education and behavioral guidance should be further strengthened to control cancer risk factors and reduce the risk of gastric cancer.
关键词
胃癌 /
病例对照研究 /
危险因素 /
多因素分析
Key words
Gastric cancer /
Case-control study /
Risk factor /
Multifactor analysis
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基金
中国消化道早癌医师共同成长计划科研项目(GTCZ-2021-AH-34-0011)
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