目的 了解长沙某哨点医院住院严重急性呼吸道感染(SARI)病例流行病学特征、临床表现等,为呼吸道感染疾病的防控和诊疗提供依据。方法 收集SARI病例咽拭子标本,相关临床表现资料,采用多重PCR快速检测试剂盒检测流感病毒(Flu)、合胞病毒(RSV)、副流感病毒(PIV)、人鼻病毒(HRV)、人偏肺病毒(HMPV)、腺病毒(AdV)、博卡病毒(HBoV)、人冠状病毒(CoV),分析病例的临床特征、呼吸道病毒流行病学特征。结果 儿科、呼吸科、重症监护室共监测534例SARI病例,呼吸道病毒阳性率为39.13%,检出210株病毒有Flu、RSV、PIV、HRV、HMPV、AdV、HBoV、CoVO,最多为RSV病毒。男性患者病毒阳性率与女性比较差异有统计学意义(χ²=55.87,P<0.05),小于3岁组病毒阳性率最高(χ²=34.2,P<0.05)。结论 SARI病例监测有利于呼吸道感染疾病的防控和临床诊疗。

Objective To evaluate the epidemiological characteristics, clinical manifestation of SARI cases in a sentinel hospital in Changsha,and provide evidence for disease prevention and control. Methods Nucleic acid of Flu, RSV, AdV, HRV, PIV HMPV, HBoV, and CoV were detected from throat swab collected from SARI cases, and the clinic and epidemiology character was analyzed. Result A total of 534 cases were collected mainly from pediatrics, respiratory and ICU departments from 2014 to 2015. The positive rate of respiratory virus was 39.13%.The Flu, RSV, AdV, HRV, PIV HMPV, HBoV, and CoV were detected within two years. The infection rate of males was higher than that of females (χ²=55.87,P<0.05) Conclusion The SARI surveillance program is helpful to prevent and cure the respiratory tract infection.