Objective To analyze the prevalence of HIV infection and AIDS patients in Susong County from 2005 to 2018,and to understand the high-risk groups and routes of HIV infection. Methods According to the basic information system of HIV/AIDS prevention and control,HIV/AIDS case surveillance data in Susong County were collected,and the HIV infection situation and infection routes of residents in Susong County were analyzed. Results From 2005 to 2018,200 HIV/AIDS cases were reported in Susong County,including 167 males and 33 females.77% of the cases were between 20 and 49 years old.The majority of the cases were farmers,houseworkers and business service providers 56.0% of the HIV/AIDS cases were married.The education level was mainly in junior high school,accounting for 41.5%.The main route of infection was sexual transmission,of which heterosexual sexual transmission accounted for 56.0%,male sexual transmission accounted for 43.0%. Conclusion The overall prevalence of HIV/AIDS in Susong County was generally at a low level,and it was in the stage of spreading from high-risk population to general population.The HIV infection was increasing rapidly.Special attention should be given to key groups such as men who have sex with men,adolescents and the elderly.Comprehensive prevention and control measures such as education and intervention should be strengthened,too.