Objective To construct the risk index models of influenza,hand-foot-mouth disease (HFMD) and other infectious diarrhea in Ma’anshan City,and to provide scientific basis for disease prediction and early warning. Methods Delphi method was used to determine the indexes in the disease risk index model and calculate the weight coefficients of each index.The calculation formulas of the risk indexes of influenza,hand-foot-mouth disease and other infectious diarrhea diseases were established.The risk indexes were calculated by converting each index data into scores according to the index scoring table,and then the risk indexes were calculated by referring to the risk level discrimination rules to get the corresponding risk level. Results The expert positive coefficient of the first round was 100%,and that of the second round was 89.5%.The authority coefficient of the two rounds of consultation experts was above 0.70.Coordination coefficients of the two rounds of consultation between experts were statistically significant (P＜0.05).Influenza risk index model: Y=0.250×X₁+0.270×X₂+0.240×X₃+0.083×X₄₁+0.079×X₄₂+0.078×X₄₃; HFMD risk index model: Y=0.130×X₁+0.130×X₂+0.320×X₃+0.143×X₄₁+0.139×X₄₂+0.138×X₄₃; other infectious diarrhea risk index model:Y=0.330×X₁+0.330×X₂+0.114×X₃₁+0.114×X₃₂+0.112×X₃₃.Compared with the actual data,the consistency rate of the model prediction was more than 70%. Conclusion The establishment of three disease risk index models in Ma'anshan City could transform the data into risk level through simple models,and play a role of disease risk indication.