Objective To analyze the occurrence of adverse events following immunization (AEFI) in Wuhe County, and to understand the completion of monitoring indicators and vaccination safety. Methods Case information and vaccination information of AEFI in Wuhe County from 2015 to 2018 were collected from National AEFI information management system in China and Anhui provincial immunization planning information system, and the incidence and causes of AEFI were analyzed. Results From 2015 to 2018, 317 cases of AEFI were reported in Wuhe County, with the reported incidence of 27.6/100000 doses by AEFI, and the reported rate within 48 hours after treatment was 100%.82.0% of the cases were children under 2 years old, 91.8% of them were scattered children.71.9% of the cases were from March to August.AEFI was reported in 14 towns in the county, and the incidence of AEFI in Linbei Township, Xiaoxi town and toupu town was the top three.All the abnormal reactions of AEFI were general reactions.The top three vaccines reported by AEFI were DTaP, MR and DT. Conclusion In Wuhe County, the incidence of AEFI is not high.DTaP, Mr and DT vaccines are important vaccines that affect AFEI.In general, the vaccination safety in Wuhe County is good.