Objective To analyze the testing rate of syphilis in maternal women and the intervention of syphilis infected pregnant women and their babies,to evaluate the effectiveness of Prevention of mother-to-child transmission(PMTCT) project in Xuancheng City. Methods The syphilis data of Xuancheng City during 2013 to 2019 from the PMTCT project information system were used to analyze the indicators of syphilis testing, treatment and follow-up of pregnant women and their newborns. Results The syphilis testing rate of maternal women was 99.97% and increased from 2013 to 2019 in Xuancheng City (χ²_trend=33.455,P<0.001).The prevalence of syphilis among maternal women was 5.21‰, and increased from 2013 to 2019 (χ²_trend=6.227,P=0.013).Among the 820 positive pregnant women, the treatment rate was 84.51%,the standard treatment rate was 60.98%.The rate of congenital syphilis was 1.98/100,000. Conclusion The syphilis detection rate and treatment rate of infected pregnant women in Xuancheng City all meet the requirements of the project plan.The syphilis PMTCT project was effective in Xuancheng City.