Objective To investigate the epidemical characteristics of Corona Virus Disease 2019 (COVID-19) in Guangdong Province. Methods The daily new confirmed cases of Corona Virus Disease 2019 (COVID-19) in Guangdong Province from January 19 to February 25,2020 were collected for epidemiological descriptive analysis.Spearman rank correlation analysis was conducted with the Baidu migration index and daily incidence in Guangdong Province. Results By February 25,2020,there was 1 347 confirmed case and the cumulative incidence of COVID-19 in Guangdong was 1.19/100,000.There was 7 case died,with a fatality rate of 0.52%(7/1 347),and the cumulative discharged proportion was 62.44%(841/1347).On January 31,2020,there was peaking that 127 new cases were diagnosed,then showing a downward trend of volatility,and on February 25,2020,the new confirmed cases were 0.The cases were mainly concentrated in the Pearl River Delta region,accounting for 89.98 percent of the province (1 212/1 347),and the cumulative incidence in the Pearl River Delta region (192/100,000) was higher than that in the non-Pearl River Delta region (0.27/100,000),with statistically significant differences (χ²=647.12,P<0.01).The incidence was 1.26/100,000 in females and 1.12/100,000 in males,with statistically significant differences (χ²=4.97,P＜0.05).The regions with the highest cumulative incidence were Zhuhai (5.18/100,000),followed by Shenzhen (3.20/100,000) and Guangzhou (2.32/100,000),with statistically significant differences (χ²=55.47,P<0.01).There was a positive correlation between daily morbidity and 5-day-before migration index in Guangdong Province (Correlation coefficient r_s =0.38,t _0.05,v =2.03,P<0.05). Conclusion The epidemic of the Corona Virus Disease 2019 has been basically controlled in Guangdong province,but control measures still need to be taken,to control the scale of foreign input population flow in an orderly manner,and obtain more accurate and comprehensive information by means of field epidemiological investigation,and adopt efficient and sensitive detection and investigation methods,improve the control ability of external defense input.