Objective To analyze the sanitary status and change trend of drinking water in Chuzhou City,and evaluate the sanitary quality of drinking water. Methods According to the “Hygienic standard for drinking water (GB5749-2006)”,the water from the factory,the peripheral water and the secondary water supply in Chuzhou City from 2016 to 2018 were monitored,and the results were analyzed and evaluated. Results A total of 1 927 water samples were detected from 2016 to 2018,and the overall qualified rate was 84.3%.The qualified rates of water samples in wet season and dry season were 76.3% and 80.5%,respectively,with significant difference (χ² = 5.021,P＜ 0.05).From 2016 to 2018,the qualified rates of rural drinking water were 63.7%,75.4% and 80.7%,with significant difference (χ² = 34.61,P＜ 0.005).The qualified rates of finished water and tap water in the three years were 77.1% and 71.2%,respectively,with significant difference (χ² = 5.61,P＜0.05).The main unqualified indexes of urban drinking water are total bacterial count and total coliform group,while the unqualified indexes of rural drinking water are total bacterial count,total coliform group,chlorine dioxide,oxygen consumption and free residual chlorine. Conclusion The quality of drinking water in Chuzhou is generally good,and the qualified rate of rural drinking water is increasing year by year.The total number of colonies and total coliform are the main unqualified indicators.Therefore,it is necessary to further urged rural township water plants to do a good job in water disinfection to ensure the quality of drinking water.