Objective To analyze the initial symptoms and medical treatment of confirmed COVID-19 cases in Anhui Province, to summarize the experience and provide scientific basis for shortening the time from the onset of confirmed cases to diagnosis and isolation. Methods The basic information of confirmed COVID-19 was from the "Chinese disease control and prevention information system", and the epidemiological data were obtained from case study of 990 novel coronavirus pneumonia cases. Results As of March 8^th, 990 confirmed COVID-19 cases and 6 deaths have been reported in Anhui Province.The average age of the patients was (43.4±15.7) years old.The first symptoms of confirmed COVID-19 cases were mostly fever (65.8%), cough (31.2%) and fatigue (12.3%).Among the 990 confirmed COVID-19 cases confirmed cases, 84 (8.5%) had a history of chronic underlying diseases, mainly including hypertension, diabetes and cardiovascular and cerebrovascular diseases.A total of 140 cases of severe and critical illness were reported.The analysis results showed that there were more cases of severe/critical illness in the age group over 60 years old.The incidence of severe/critical illness was higher in patients with hypertension and diabetes.The proportion of severe/critical illness was higher in the first private clinic/village clinic.And all differences were statistically significant (all P＜ 0.05).The longer the time from onset to isolation, the higher the proportion of confirmed cases would appear in close cases. Conclusion The first symptoms of confirmed covid-19 cases in Anhui province are mainly fever.Medical institutions at all levels should strengthen the early recognition of the disease, so as to achieve early detection, early diagnosis, early isolation and early treatment.