Objective To understand the etiological characteristics of hand foot mouth disease (HFMD) in Feixi County from 2011 to 2018 and provide support for medical treatment of HFMD. Methods The incidence data of HFMD were collected from infectious disease reporting information management system.The descriptive epidemiological method was used to analyze the data.627 samples of HFMD patients were collected for detection of enterovirus nucleic acid by fluorescent RT-PCR. Results From 2011 to 2018,627 hand foot mouth cases were detected,411 cases were positive for enterovirus nucleic acid,and the positive rate was 65.55%.Among them,EV71 accounted for 38.44%,CVA 16 accounted for 27.74%,and other enteroviruses accounted for 33.82%.The positive composition of EV71,CVA 16 and other enteroviruses was different in each year,and the difference was statistically significant(χ2=102.10,P＜0.001).The difference of EV71 positive rate between severe cases and common cases was statistically significant(χ2=9.300,P=0.002).There was no significant difference in the positive rate between male and female(χ2=0.001,P=0.978).Most of the patients were children under 5 years old. Conclusion From 2011 to 2018,the pathogen spectrum of HFMD changed,the composition of EV71 decreased,and the composition of other enteroviruses increased.Attention should be paid to the influence of the change of etiological test results on the incidence of hand foot mouth disease.
Key words
Hand-foot-mouthdisease /
Etiology /
Enterovirus
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