Research advances on the role of leptin in mental disorders

ZHANG Ye-lei, ZHANG Kai, LIU Huan-zhong

Anhui Journal of Preventive Medicine ›› 2020, Vol. 26 ›› Issue (5) : 364-367.

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Anhui Journal of Preventive Medicine ›› 2020, Vol. 26 ›› Issue (5) : 364-367. DOI: 10.19837/j.cnki.ahyf.2020.05.009

Research advances on the role of leptin in mental disorders

  • ZHANG Ye-lei, ZHANG Kai, LIU Huan-zhong
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Abstract

Leptin is a non-glycosylated peptide hormone encoded by the obesity gene, exerts biological effects and enhances immune system function by binding to leptin receptors.Leptin receptors are widely distributed in brain tissues including the cortex, amygdala, hippocampus, and thalamus, so leptin may have a wide range of roles in the onset and development of mental disorders.This article will review the role of leptin in common mental disorders such as depression, anxiety, schizophrenia and autism.It is hoped that this article will provide readers with a more comprehensive understanding of the role of leptin in the mental disorders.

Key words

Leptin / Depressive disorder / Anxiety disorder / Schizophrenia / Autism disorder / Rett syndrome

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ZHANG Ye-lei, ZHANG Kai, LIU Huan-zhong. Research advances on the role of leptin in mental disorders[J]. Anhui Journal of Preventive Medicine. 2020, 26(5): 364-367 https://doi.org/10.19837/j.cnki.ahyf.2020.05.009

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