Objective To analyze the epidemiological features of COVID-19 infection in women and children in Hefei. Methods A descriptive epidemiological study was conducted to retrospectively analyze the epidemiological features of confirmed COVID-19 cases and asymptomatic infections among women and children during January 23 to March 6,2020. Results During the observation period,112 cases of new coronavirus infection occurred in women and children in Hefei City,including 84 confirmed cases and 28 asymptomatic cases.66.7% of the novel coronavirus pneumonia infection was transmitted locally.The median time between onset and confirmed was 6.5 days.The age of the group was mainly 30-59 years old (62.5%),and the occupation was mainly housework and unemployed (22.3%).The clinical classification of 84 confirmed cases was mainly common type (81.0%),and the clinical classification was heavier with age (linear trend χ²=5.252,P=0.034).The overall secondary infection rate of the close contacts of the confirmed cases was 8.16%,and that of the asymptomatic infections was 1.79%.The secondary infection rate of the confirmed cases was higher than that of the asymptomatic infected patients,with statistically significant differences (χ²=34.505,P＜0.001).Most of the infections found in close contacts are related to confirmed cases and asymptomatic infections. Conclusion The COVID-19 infection among women and children in Hefei was mainly transmitted locally,and family members in close contact were at high risk of infection.