Objective To analyze the correlation between the expression of epidermal growth factor receptor 3 (ErbB3) protein in plasma and overweight,and to explore the role of ErbB3 in overweight. Methods 128 adults aged 33-79 were recruited from the physical examination center of Yijishan hospital from July to August in 2019. Body mass index (BMI) ≥24.0 Kg/m2 was used as overweight,and BMI<24.0 Kg/m2 was used as control. Plasma ErbB3 level was assessed by the Enzyme-linked immunosorbent assay (ELISA). Results In the male population,the plasma ErbB3 level in overweight group was lower than that in the control group. In the drinking population,the level of ErbB3 in overweight population was also significantly reduced,and the difference was statistically significant(P<0.05). The level of ErbB3 was negatively correlated with BMI in males(r = -0.252,P= 0.034)and drinking population(r=-0.389,P=0.008). Conclusion In males and drinkers,the decrease of ErbB3 level is associated with adult overweight.
Key words
ErbB3 /
Epidermal growth factor receptor /
Overweight /
Obesity
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