Effects of occupational lead exposure on blood routine and liver function indexes

ZHAO Pan; ZHANG Jing; LIU Bi-yong

doi:10.19837/j.cnki.ahyf.2021.02.010

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Anhui Journal of Preventive Medicine ›› 2021, Vol. 27 ›› Issue (2) : 123-125. DOI: 10.19837/j.cnki.ahyf.2021.02.010

Effects of occupational lead exposure on blood routine and liver function indexes

ZHAO Pan, ZHANG Jing, LIU Bi-yong

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Abstract

Objective To analyze the influence of occupational lead exposure on patient’s blood routine and liver function,and to explore the toxic effects of lead on the body. Methods 87 occupational lead exposures were the research group,and 76 people who had a physical examination at the Anhui Prevention and Treatment Center for Occupational Disease during the same period were the control group.The blood samples were collected from the two groups.The blood lead level was detected by atomic absorption spectrophotometer.The blood routine indexes were detected by automated hematology analyzer.The liver function indexes were detected by automatic biochemical analyzer.The related indexes of the two groups were analyzed. Results The abnormal rates of hemoglobin (Hgb),platelet count (PLT) and reticulocyte count (RET) in the research group were significantly higher than those in the control group (P＜0.01).The abnormal rates of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the research group were higher than those in the control group (P＜0.01). Conclusion Occupational lead exposure can lead to abnormal blood routine and liver function.

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Occupational lead exposure / Blood lead / Blood routine / Liver function

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ZHAO Pan, ZHANG Jing, LIU Bi-yong. Effects of occupational lead exposure on blood routine and liver function indexes[J]. Anhui Journal of Preventive Medicine. 2021, 27(2): 123-125 https://doi.org/10.19837/j.cnki.ahyf.2021.02.010

References

[1] 吕敏.职业接触铅人群生物标志物的研究[D].苏州:苏州大学,2010.
[2] Coutselinis A,Trichopoulos D,Zavitsianos X.Low blood lead concentrations and hemopoiesis[J].Clinical chemistry,2019,25(7):1339.
[3] Harari F,Sallsten G,Christensson A,et al.Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort[J].American Journal of Kidney Diseases,2018,72(3):381-389.
[4] Cai Y,Fang W,Wen Y,et al.Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers[J].Occupational&Environmental Medicine,2019,76(6):82-88.
[5] Chen Y,Xu X,Zeng Z,et al.Blood lead and cadmium levels associated with hematological and hepatic functions in patients from an e-waste-polluted area[J].Chemosphere,2019,220:531-538.
[6] Almeida Lopes ACB,Ailbergeld EK,Navas-Acien A,et al.Association between blood lead and blood pressure: a population-based study in Brazilian adults[J].Environmental Health,2018,17(1):16.
[7] Zhai H,Chen C,Wang N,et al.Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization[J].Environmental Health,2017,16(1):93.
[8] 国家卫生和计划生育委员会.职业性慢性铅中毒标准: GBZ 37-2015[S].北京: 中国标准出版社,2015.
[9] 中华人民共和国国家卫生健康委.血中铅的石墨炉原子吸收光谱测定方法:WS/T 20-1996[S].北京:人民卫生出版社,2018.
[10] 张小凡,马佳智,许彬,等.分光光度法测定尿中δ-氨基乙酰丙酸的条件优化[J].中国工业医学杂志,2017,30(6): 465-466.
[11] Wani AL,Ara A,Usmani JA.Lead toxicity: a review[J].Interdiscip Toxicol,2015,(892):55-64.
[12] Chen X,Zhou H,Li X,et al.Effects of lead and cadmium coexposure on hemoglobin in a Chinesepopulation[J].Ecviron Toxicol Pharmacol,2015,39(2): 758-763.
[13] 杨玉新,孙晓静,赵海涛,等.铅作业工人血铅水平和肝功能状况及其影响因素[J].职业卫生与应急救援,2019,37(2):113-117,125.
[14] 何晓庆,裘淑华.职业性铅接触工人血铅及肝功能指标的变化[J].环境与职业医学,2010,27(11): 660-663.
[15] 何晓庆,裘淑华.宜兴市蓄电池行业铅危害分析[J].江苏预防医学,2011,22(1): 47-48.