Objective To analyze the epidemic characteristics of COVID-19 in Zhoukou City and discuss the prevention and control countermeasures. Methods Descriptive epidemiological method was used to analyze the COVID-19 surveillance data and related data in Zhoukou City from January 1,2020 to December 31,2020. Results From January 23 to February 17,2020 (no COVID-19 cases were found after February 18),a total of 76 confirmed cases of COVID-19 were reported in Zhoukou City,with an incidence rate of 0.87/100,000.The mean age of onset was (42.28±14.99) years old.Farmers,commercial service workers,domestic workers and unemployed workers accounted for 82.89% of the cases,and there was a statistically significant difference in the composition ratio of the number of cases among different occupational groups (χ²=63.529,P＜ 0.05).A total of 43 patients had a history of living in Wuhan City,and 33 patients had indirect exposure related to Wuhan City.There were 13 clustered outbreaks involving 43 cases,of which 29 were local secondary cases.84.62% of the cluster cases were mainly caused by exposure in Wuhan City,such as family life gathering,classmates dining together,returning home together,and medical activities. Conclusion The COVID-19 cases in Zhoukou City were mainly caused by direct and indirect exposure transmission related to Wuhan City.Interpersonal transmission occurs mainly in close contact in family life and gathering activities.Local transmission of the epidemic has been basically blocked,and a scientific and precise strategy should be implemented to prevent the epidemic rebound caused by imported cases from abroad and contamination of cold-chain food.