Objective To understand the death level and causes of residents. Methods The death data of the registered population in Quanzhou City in 2018 were collected and analyzed using Excel 2017 and SPSS20.0 statistical software.Descriptive epidemiological method was used for analysis. Results In 2018,the mortality rate of Quanzhou residents was 477.98/100000,the standardized mortality rate was 441.58/100000,and the ratio of male and female mortality was 1.43:1.The age distribution of death showed a "√" shape,and the death rate of children aged 5 to 9 was the lowest (11.00/100,000).The mortality rate of chronic non-communicable diseases was 382.50/100000,accounting for 80.02% of all deaths.The top five death causes were malignant tumor,cerebrovascular disease,heart disease,injury and poisoning,respiratory diseases,accounting for 78.92% of all causes of death.The male mortality rate of the top five death causes were higher than that of the female.Malignant tumor was the first death cause in the age group of 15 and above.The death rate of lung cancer and esophageal cancer were higher than that of other malignant tumors,and they were the main death causes of malignant tumors in the whole population and people aged 65 and above. Conclusion Chronic non-communicable diseases such as malignant tumors and cerebrovascular diseases have become the main causes of death in Quanzhou City.