Objective To explore the effect of comprehensive intervention measures on poor eyesight of primary school students. Methods All the students in two primary schools with similar conditions in Hebi City were selected as the research objects.The students in one school were given comprehensive prevention and control intervention,and the students in the other school were given routine prevention and control measures.One year later,the incidence of poor eyesight of the students in the two schools was compared. Results After the intervention,the detection rate of poor eyesight was 25.31% in the intervention group and 29.48% in the control group,the difference was statistically significant(χ²=6.840,P=0.011).The results showed that more students in the intervention group were in the normal level,while more students in the control group were in the moderate and severe poor eyesight level,the difference was statistically significant(χ²=14.011,P=0.003). Conclusion The comprehensive intervention on the prevention and control of poor eyesight in primary school plays an obvious role in improving students' poor eyesight.