Evaluation of combined immunologic effect of hepatitis B immunoglobulin and hepatitis B vaccine to block mother-to-child transmission of hepatitis B in Wuhu City

WU Wei-lin; WANG Rui; WANG Run; RUI Ting-ting; CAO Zhen; TAO Qing

doi:10.19837/j.cnki.ahyf.2021.05.011

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Anhui Journal of Preventive Medicine ›› 2021, Vol. 27 ›› Issue (5) : 374-376. DOI: 10.19837/j.cnki.ahyf.2021.05.011

Evaluation of combined immunologic effect of hepatitis B immunoglobulin and hepatitis B vaccine to block mother-to-child transmission of hepatitis B in Wuhu City

WU Wei-lin, WANG Rui, WANG Run, RUI Ting-ting, CAO Zhen, TAO Qing

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Abstract

Objective To observe the effect of hepatitis B immunoglobulin (HBIG) combined with hepatitis B vaccine (HepB) on blocking the transmission of hepatitis B virus in Wuhu City. Methods Infant Serum samples from 319 pregnant women with positive hepatitis B virus surface antigen (HBsAg) were collected from April 2017 to December 2019 in Wuhu City.All infants were injected with 100 international units (IU) HBIG in 24h after delivery,and 3 doses of hepatitis B vaccine were received according to the "0-1-6" vaccination procedure.During the 1~6 months after the completion of the third dose of hepatitis B vaccination,that is,when children were 7 month old to 12 month old,they would be recalled to detect hepatitis B to evaluate the immune effect. Results The negative rate of HBsAg in infants was 98.43%,and the positive rate of HBsAb in infants was 98.12%.There was significant difference in the negative rate of HBsAg in infants between the mother's HBeAg positive group and the negative group (Fisher’ exact probability P=0.005).There was significant difference in the positive rate of HBsAb in infants. Conclusion The combined immunization of HBIG and HepB has a significant effect in blocking mother-to-child transmission of hepatitis B.

Key words

Hepatitis B immunoglobulin / Hepatitis B vaccine / Hepatitis B virus / Mother-to-child transmission interruption / Immune effect evaluation

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WU Wei-lin, WANG Rui, WANG Run, RUI Ting-ting, CAO Zhen, TAO Qing. Evaluation of combined immunologic effect of hepatitis B immunoglobulin and hepatitis B vaccine to block mother-to-child transmission of hepatitis B in Wuhu City[J]. Anhui Journal of Preventive Medicine. 2021, 27(5): 374-376 https://doi.org/10.19837/j.cnki.ahyf.2021.05.011

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