The Application and Critical Control Point of Formaldehyde During the Manufacturing of Vaccine Products

SAI Wen-bo; GUO Sheng-nan; GUO Shu-yang

doi:10.19837/j.cnki.ahyf.2021.06.016

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Anhui Journal of Preventive Medicine ›› 2021, Vol. 27 ›› Issue (6) : 483-486. DOI: 10.19837/j.cnki.ahyf.2021.06.016

The Application and Critical Control Point of Formaldehyde During the Manufacturing of Vaccine Products

SAI Wen-bo, GUO Sheng-nan, GUO Shu-yang

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Abstract

As a commonly used detoxifying agent or inactivating agent,formaldehyde can form a stable and irreversible connection with the amino or sulfhydryl group of protein,and then lead to protein inactivation,so it is widely used in the manufacturing process of various vaccine products,such as toxoid vaccine and virus inactivated vaccine.On the other hand,the tragedies caused by incomplete virus inactivation in history also remind researchers to pay full attention to the safety and effectiveness of formaldehyde in the manufacturing process.This paper summarizes the current use of formaldehyde in the manufacturing process of vaccine products from three aspects: formaldehyde application examples,manufacturing process and safety control points,and the limitations of the use of formaldehyde,in order to provide some reference for the development of this kind of products.

Key words

Formaldehyde / Vaccine Product / Manufacturing Process / Safety Control / Limitations

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SAI Wen-bo, GUO Sheng-nan, GUO Shu-yang. The Application and Critical Control Point of Formaldehyde During the Manufacturing of Vaccine Products[J]. Anhui Journal of Preventive Medicine. 2021, 27(6): 483-486 https://doi.org/10.19837/j.cnki.ahyf.2021.06.016

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