Objective To investigate the level of IgG antibody in serogroup A and C of epidemic cerebrospinal meningitis among healthy population in Kaifeng City,and to provide theoretical basis for prevention and control of epidemic cerebrospinal meningitis. Methods A total of 1003 subjects in 7 age groups,including <1 year,1-2 years,3-4 years,5-6 years,7-14 years,15-19 years and ≥ 20 years in Luowang Township and Dalizhuang Township of Kaifeng City from 2019 to 2020 were selected as study subjects using a random stratified sampling method.Enzyme-linked immunosorbent assay was used to detect the IgG antibody levels in serogroupp A and serogroup C of epidemic cerebrospinal meningitisserum. Results The positive rate of meningococcal serogroup A and C IgG in healthy population in Kaifeng City were 49.85% and 54.84%,respectively.The positive rate of meningococcal serogroup A (χ²=162.674,p＜0.001) and C (χ²=140.422,P＜0.001) were significantly different in different age groups.The positive rate of meningococcal serogroup A and C IgG antibody positivity rates were both the lowest in the <1 year old group.The IgG positive rate of serogroup A was highest in the≥20 age group.The IgG positive rate of serogroup C was highest in the 3～4 age group.Positive rate was higher in people with immunization history than in people without immunization history and people with unknown immunization history.The antibody positivity rate was higher when the vaccination period is about one year. Conclusion In Kaifeng,the serum IgG antibody levels of meningococcal serogroup A and C are relatively low in healthy population,especially in the<1 year old group.Hence,the vaccination of meningococcal vaccine should be enhanced to improve the coverage rate of meningococcal vaccine and raise the antibody level of epidemic cerebrospinal meningitis in the population.