Objective To analyze the epidemic characteristics of hand,foot and mouth disease(HFMD) in Yudu County from 2016 to 2020. Methods By collecting the data from the China Disease Prevention and Control Information System and pathogenic surveillance,the epidemiological characteristics and etiological changes of HFMD were analyzed by descriptive epidemiological method. Results A total of 6,093 HFMD cases were reported in Yudu County from 2016 to 2020 without severe or fatal cases.The average annual reported incidence of HFMD was 139.85/100,000,and the reported incidence in different years showed a decreasing trend (χ²_trend =1036.04,P＜0.001).The onset time showed a bimodal distribution with two peaks in May to July and September to November,respectively.The incidence of the disease was higher in male than in female (χ²=509.84,P＜0.001).Cases were concentrated in children under 4 years old,with 5 360 cases reported,accounting for 87.97%.Of these,diaspora children were the majority,with 5 005 cases reported,accounting for 82.14%.The positive rate of the pathogen specimens was 69.75%,with other enteroviruses,EV71,and CoxA16 accounting for 71.07%,8.26% and 20.66%,respectively.Notably,EV71 pathogen was not detected after 2018. Conclusion The incidence of HFMD in Yudu County from 2016 to 2020 showed a decreasing trend with distinct epidemiological characteristics.In view of the high incidence seasons of HFMD,key areas and the children under 4 years old,it is necessary to strengthen the intervention and the propaganda work,promote EV71 vaccination,and continue to do a good job in pathogenic surveillance.