Objective To explore the effect of comprehensive intervention measures in improving the rate of pathogenic inspection before antibiotic treatment in hospitals and preventing and controlling bacterial resistance. Methods The research subjects were divided into the experimental group and the control group according to whether comprehensive intervention measures were implemented.The control group and the experimental group were compared and analyzed in terms of specimen submission,pathogen detection,multidrug-resistant bacteria detection,and multidrug-resistant bacteria in hospital-acquired infection before antibiotic treatment during hospitalization. Results In the intervention group,the detection rate of pathogenic specimen for therapeutic use of antimicrobials was 85.27% ,and the control group was 58.79%,with a statistically significant(χ2=416.678,P＜0.001);there was a statistically significant difference in the composition ratio of etiological specimen types between the two groups (χ2=12.610,P=0.006);there was a statistically significant difference in the number of strains of iatrogenic infection between the two groups (χ2=1.786,P=0.018);the detection rate of multi-drug resistant bacteria was 52.63% in the intervention group and 33.91% in the control group,and the difference between the two groups was statistically significant (χ2=12.967,P＜0.001). Conclusion Taking comprehensive intervention measures can effectively improve the detection rate of pathogenic microorganisms before the therapeutic use of antibiotics,reduce the nosocomial spread of multidrug-resistant bacteria,effectively contain and delay the emergence of drug resistance of pathogenic bacteria.
Key words
Rational use of antibiotics /
Bacterial resistance /
Intervention measures /
Hospital infection control
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