Objective To understand the trend of death cause distribution,life expectancy and mortality in Jinghu District of Wuhu City from 2016 to 2020. Methods According to the 2016—2020 monitoring data on the causes of death of residents in Jinghu District,Wuhu City,the International Classification of Diseases (ICD-10) was used for coding,and the codes of fundamental death causes were divided into 3 categories and 19 subcategories for analysis.The mortality rate (MR),standardized mortality rate (SMR),age-specific mortality rate (ASDR),order of death causes,life expectancy per capita(LE₀) and cause-free life expectancy (LE^－e₀) and other indicators in Jinghu District,Wuhu City from 2016 to 2020 were analyzed. Results From 2016 to 2020,the MR and SMR of Jinghu District residents were 567.38/100,000 and 519.21/100,000,respectively.The top five causes of death were malignant tumor,cerebrovascular disease,heart disease,respiratory disease and injury.Among the top five causes of death,cerebrovascular disease and heart disease had greater influence on female LE₀ than male LE₀,and the other three causes of death had greater influence on male LE₀ than female LE₀. Conclusion Chronic non-communicable diseases have become the main causes of death for residents.Health policies should be developed with prevention and control measures based on variables such as gender and age.At the same time,male and elderly people should be the focus of the later prevention and control work.