Objective To analyze the epidemiological situation of tuberculosis (TB) in Hefei High-tech Zone from 2011 to 2020,to understand the epidemiological trend,and to provide theoretical basis for the formulation of prevention and control policies. Methods Using descriptive epidemiological methods,the 10-year incidence of TB reported in the Chinese Disease Surveillance Information Reporting System in Hefei High-tech Zone was analyzed. Results A total of 464 cases of TB were reported in Hefei High-tech Zone from 2011 to 2020,with an average incidence of 48.12/100 000.The highest incidence of TB was 64.86/100 000 in 2018 and the lowest was 28.28/100 000 in 2012.The TB incidence showed a fluctuating upward trend (χ²=2.971,P<0.05).The highest incidence of 150.23/100 000 was found in people aged 70 years and above.The incidence rate in male was higher than in female,and the difference was statistically significant (χ²=43.052,P<0.01).The incidence was higher in the non-domiciled population than in the domiciled population,and the difference was statistically significant (χ²= 265.848,P<0.001).The number of cases in the household and non-working population was largest,accounting for 23.49% (109/464). Conclusion The characteristics of TB incidence in Hefei High-tech Zone are outstanding.The prevention and control of TB should be strengthened by taking into account the demographic characteristics.