Objective To understand the use behavior of Maternal and Child Health Manual APP and its influencing factors,so as to provide a scientific basis for improving the function of Maternal and Child Health Manual APP and the compliance of service objects. Methods A cluster sampling method was used to conduct a questionnaire survey on the basic information and the use of Maternal and Child Health Manual APP among 1 124 subjects in medical institutions of various counties and districts in Huaibei City from January to February 2021.The χ²test and logistic regression model were used to analyze residents' use of the APP and its influencing factors. Results The utilization rate of Maternal and Child Health Manual APP was 56.05%.Multivariate logistic regression analysis showed that knowing about the APP (OR=1.548,95%CI:1.048-2.287),understanding about the APP (OR=2.509,95%CI:1.745-3.609),trusting the APP (OR=4.592,95%CI:3.140-6.716),satisfaction with the overall evaluation of the APP (OR=2.978,95%CI:2.092-4.239),the functions and medical knowledge pushed by the APP to meet the needs (OR=5.308,95%CI:3.677-7.662) and having searched for relevant health information in the last 6 months (OR=9.218,95%CI:6.280-13.528) were associated with high usage of the APP.However,having a history of fertility was associated with low Mother and Child Health Handbook APP usage (OR=0.367,95%CI:0.260-0.520). Conclusion The utilization rate of Maternal and Child Health Manual APP is low.The security of regulatory information should be enhanced,focusing on the needs of service objects,improving APP use and medical treatment experience,and ultimately improving patients' compliance in using APP.