Objective To understand the epidemiological characteristics of AIDS in Tongling City by analyzing the epidemic situation of AIDS in Tongling City from 2012 to 2021. Methods Descriptive statistical method was used to analyze newly reported HIV/AIDS case data from 2012 to 2021 in Tongling based on the China Information System for Disease Control and Prevention. Results A total of 412 HIV/AIDS cases were reported from 2012 to 2021 in Tongling City,including 218 HIV infected patients and 194 AIDS patients.Among the reported cases,52 cases died,with an average annual reported incidence rate of 2 600/100 000.There were case reports in three districts and one county of the city.The annual average incidence rate of Zongyang County was the highest,and that of Yi'an District was the lowest.Among the reported cases,men accounted for a large proportion,with a sex ratio of 5.54∶1.The age of onset was mainly concentrated in the age group of 20-59 years old,and the proportion of the age group of 50 years old and above was increasing year by year.The occupational distribution was mainly focused on household chores,unemployment,and farmers.Sexual transmission was the main transmission route,and the proportion of male sex transmission had been increasing year by year.From 2013 to 2019,the proportion increased from 24.14% to 41.67%.The detection method was mainly passive detection. Conclusion From 2012 to 2021,the prevalence of AIDS in Tongling City was at a low level,mainly transmitted by men and men.