Objective To investigate and analyze the outbreak and control of suspected carbapenem-resistant Klebsiella pneumoniae (CRKP) hospital infection in the intensive care unit (ICU) of a hospital,and to provide reference for improving nosocomial infection control. Methods This study conducted an epidemiological investigation of CRKP patients in the ICU and carried out environmental hygiene inspections of the ICU ward.Then the corresponding measures were taken. Results The results showed that six out of eight patients detected with CRKP had consistent antibiotic resistance.All cases had overlapping hospitalization time and adjacent bed.The janitor for the six patients served as the same person in charge.The CRKP detected on the cleaner's hand,ventilator and monitoring instrument surfaces,and window rails were consistent with the drug sensitivity results of the six patients.After implementing measures such as increasing the frequency of environmental cleaning and disinfection,strengthening hand hygiene,and enhancing personnel management and hospital infection prevention and control training,the outbreak of hospital infection was effectively controlled. Conclusion The study concludes that the improper execution of hand hygiene by the cleaning staff and inadequate environmental cleaning and disinfection in the ward are the main reasons for the suspected CRKP hospital infection outbreak in the ICU.Timely judgment and cause investigation and the adoption of appropriate prevention and control strategies can effectively control hospital infection outbreaks.