Identification and transmission risk assessment of type I vaccine-derived poliovirus in Anhui Province in 2023

HE Jiali; WANG Binbing; WANG Xin; SU Ying; CHENG Pengbo; DONG Yan; SONG Feiyang; CHENG Xiaodong

doi:10.19837/j.cnki.ahyf.2024.01.010

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Anhui Journal of Preventive Medicine ›› 2024, Vol. 30 ›› Issue (1) : 43-46. DOI: 10.19837/j.cnki.ahyf.2024.01.010

Original Articles

Identification and transmission risk assessment of type I vaccine-derived poliovirus in Anhui Province in 2023

HE Jiali, WANG Binbing, WANG Xin, SU Ying, CHENG Pengbo, DONG Yan, SONG Feiyang, CHENG Xiaodong

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Abstract

Objective To analyze the genotypes and characteristics of two vaccine-derived poliovirus (VDPV) strains isolated from a non-acute flaccid paralysis (non-AFP) case in Anhui Province in 2023,and to explore the influence of this case on maintaining polio-free status in Anhui province. Methods Poliovirus (PV) was isolated from two samples of a non-AFP case in Anhui Province in 2023.The PV was identified by real time fluorescent quantitative RT-PCR.The single type strain was obtained by neutralization experiment,the viral RNA was extracted and amplified by RT-PCR,and the nucleotide sequence of VP1 region was determined and analyzed. Results Two mixed type I+III PV strains were isolated from the double fecal samples of the non-AFP case.Type I (2023MYKJH 01-1 and 2023MYKJH 01-2) had 13 and 12 nucleotide variants,with variation rates of 1.4% and 1.3%,respectively,they were identified as type I VDPV and in a different branch from the type I VDPV detected in other province in China in recent years.Type III were vaccine-like strains.Type I VDPV was not isolated from subsequent stool samples. Conclusion One non-AFP case of two type I VDPV strains detected in Anhui Province in 2023 did not undergo continuous detoxification,resulting in a lower risk of developing type I VDPV circulation.

Key words

Vaccine-derived polioviruses / Intratypic differentiation / Sequence analysis

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HE Jiali, WANG Binbing, WANG Xin, SU Ying, CHENG Pengbo, DONG Yan, SONG Feiyang, CHENG Xiaodong. Identification and transmission risk assessment of type I vaccine-derived poliovirus in Anhui Province in 2023[J]. Anhui Journal of Preventive Medicine. 2024, 30(1): 43-46 https://doi.org/10.19837/j.cnki.ahyf.2024.01.010

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