Objective To investigate the clinical symptoms and complications of patients infected with Omicron variant of SARS-CoV-2,and provide evidence for the prevention and treatment of coronavirus disease 2019 (COVID-19). Methods A questionnaire was used to investigate the epidemiology of infected people who had been classified by whole genome sequencing of SARS-CoV-2 variant strains in Anhui Province.The factor analysis of the clinical symptoms and complications of people infected with different variant strains was analyzed by SPSS 22.0 software. Results In total,1 033 patients infected with the Omicron variant were collected,including 436 cases of the BA.5 subvariant (42.2%) and 597 cases of the XBB subvariant(57.8%).10.7% of infected individuals were asymptomatic,the proportion of asymptomatic infections among those infected with the XBB subvariant was higher than that of the BA.5 subvariant(χ2=36.870,P＜0.001).The proportion of fever and chest tightness among those infected with the BA.5 subvariant was higher than that of those infected with the XBB subvariant.In contrast,patients infected with XBB subvariant presented more symptoms of headache,sore throat,nasal congestion,and runny nose(P＜0.05)).105 (24.1%) infected patients developed related complications,and the severe disease rate among patients infected with the BA.5 subvariant was higher than that of the XBB subvarians(χ2=52.154,P＜0.001).The rate of severity was lower in those who had been vaccinated and those who had been fully vaccinated with COVID-19 vaccine (P< 0.05).Moreover,those who over 60 years old and patients(OR=2.534,95%CI:1.090-5.892)with expectoration symptoms (OR=2.680,95%CI:1.305-5.502)were at higher risk of acute phase. Conclusion Most people infected with Omicron variants developed clinical symptoms, and the incidence of complications and severe diseases is low.There were differences in clinical features between the BA.5 subvariant and the XBB subvariant.Age and the presence or absence of sputum symptoms affect the severity rate of Omicron variant infections.More attention should be paid to the evolutionary trends of Omicron variant strains,early identification of clinical symptoms should be strengthened,and follow-up work should be carried out for the prognosis of infected individuals.
Key words
SARS-CoV-2 /
Variant /
Omicron /
Clinical symptoms /
Complication
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