Application progress of high resolution mass spectrometry technology in high throughput detection of food safety pollutants

LIU Bolin, ZHUANG Meihui, ZHAO Ziwei, XIE Ji′an

Anhui Journal of Preventive Medicine ›› 2024, Vol. 30 ›› Issue (3) : 230-234.

PDF(869 KB)
PDF(869 KB)
Anhui Journal of Preventive Medicine ›› 2024, Vol. 30 ›› Issue (3) : 230-234. DOI: 10.19837/j.cnki.ahyf.2024.03.012
Review

Application progress of high resolution mass spectrometry technology in high throughput detection of food safety pollutants

  • LIU Bolin, ZHUANG Meihui, ZHAO Ziwei, XIE Ji′an
Author information +
History +

Abstract

Exploring the pollution status of chemical pollutants in food and establishing accurate,high throughput rapid screening and detection technologies for targeted and non-targeted chemical pollutants has become a research hotspot in the field of food safety.High resolution mass spectrometry (HRMS),as an analytical technique,not only has the advantages of accurate quantification by triple quadrupole mass spectrometry,but also has the function of high throughput rapid qualitative screening and resolving unknown structures.It is widely used in the field of food safety.This article reviews the application of high resolution mass spectrometry in the detection of agricultural and veterinary drug residues,food additives,and food poisoning.It analyzes the development and application status of common high resolution mass spectrometry technologies such as quadrupole time of flight mass spectrometry,orbitrap mass spectrometry,double focusing mass spectrometer,and Fourier transform ion cyclotron resonance mass spectrometry.

Key words

Food safety / High resolution mass spectrometry / Pesticide residues / Veterinary drug residues / Food additives / Food poisoning

Cite this article

Download Citations
LIU Bolin, ZHUANG Meihui, ZHAO Ziwei, XIE Ji′an. Application progress of high resolution mass spectrometry technology in high throughput detection of food safety pollutants[J]. Anhui Journal of Preventive Medicine. 2024, 30(3): 230-234 https://doi.org/10.19837/j.cnki.ahyf.2024.03.012

References

[1] 国家卫生健康委员会,农业农村部,国家市场监督管理总局.食品安全国家标准 食品中农药最大残留限量:GB 2763—2021[S].北京:中国标准出版社,2021.
[2] 国家卫生健康委员会,农业农村部,国家市场监督管理总局.食品安全国家标准 食品中2,4-滴丁酸钠盐等112种农药最大残留限量:GB 2763.1—2022[S].北京:中国标准出版社,2022.
[3] 中华人民共和国农业农村部,国家卫生健康委员会,国家市场监督管理总局.食品安全国家标准 食品中兽药最大残留限量:GB 31650—2019[S].北京:中国标准出版社,2019.
[4] 中华人民共和国农业农村部,国家卫生健康委员会,国家市场监督管理总局.食品安全国家标准 食品中41种兽药最大残留限量:GB 31650.1—2022[S].北京:中国标准出版社,2022.
[5] 中华人民共和国农业农村部.中华人民共和国农业农村部公告第250 号(2020-01-06)[2023-06-24].http://www.moa.gov.cn/govpublic/xmsyj/202001/t20200106_6334375.htm.
[6] 王聪,梁瑞强,曹进,等.高分辨质谱在食品检测分析中的应用进展[J].食品安全质量检测学报,2018,9(5):1038-1044.
[7] 孟哲,石志红,吕运开,等.超高效液相色谱-高分辨四级杆飞行时间质谱法快速筛查乳制品中磺胺类与氟喹诺酮类药物[J].分析化学,2014,42(10):1493-1500.
[8] 宋伟,赵暮雨,韩芳,等.超高效液相色谱-四极杆飞行时间质谱法测定克氏螯虾中39种兽药残留[J].色谱,2018,36(12):1261-1268.
[9] 王振聚,罗忻,梁生康,等.高分辨质谱技术在全氟多氟化合物分析中的应用研究进展[J].分析测试学报,2022,41(6):931-940.
[10] 黄芳,邓欣,罗辉泰,等.傅立叶变换离子回旋共振质谱法分析铝材封闭剂中的成分[J].分析测试学报,2019,38(5):569-573.
[11] 陈超,罗辉泰,张秋炎,等.基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱法快速测定全血及尿液中的百草枯[J].分析测试学报,2020,39(9):1126-1130.
[12] 李二庭,史权,马聪,等.生物降解稠油极性化合物负离子电喷雾傅立叶变换离子回旋共振质谱分析[J].石油实验地质,2022,44(3):515-521.
[13] 马超,倪洪星,戚羽霖.超高效液相色谱-傅里叶变换离子回旋共振质谱法解析溶解性有机质的化学多样性[J].色谱,2023,41(8):662-672.
[14] Zhang YM,Zhao M,Liu T,et al.Rapid characterization of the chemical constituents of Yinchen Wuling Powder by UPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry[J].J Pharm Biomed Anal,2021,198:114022.
[15] 杨秋霞,杨运云,刘耀慧,等.傅立叶变换离子回旋共振质谱法对赤灵芝的化学成分鉴定和指纹图谱研究[J].分析测试学报,2019,38(5):525-531.
[16] 王红,沈伟健,陈国强,等.同位素稀释高分辨气相色谱-高分辨磁质谱法测定大闸蟹中二噁英及其类似物[J].食品安全质量检测学报,2021,12(10):4142-4149.
[17] 丰东升,王霞,李雪颖,等.气相色谱-四极杆/飞行时间质谱法非靶向快速筛查葡萄中农药多残留[J].农产品质量与安全,2022(5):31-37.
[18] 门雪,吴兴强,仝凯旋,等.改进的QuEChERS法结合液相色谱-高分辨质谱筛查热带水果中33种新烟碱类杀虫剂及杀菌剂[J].分析测试学报,2022,41(6):820-826.
[19] Liang SX,Li H,Chang QY,et al.Residual levels and dietary exposure risk assessment of banned pesticides in fruits and vegetables from Chinese market based on long-term nontargeted screening by HPLC-Q-TOF/MS[J].Ecotoxicol Environ Saf,2022,248:114280.
[20] Makni Y,Diallo T,Guérin T,et al.Improving the monitoring of multi-class pesticides in baby foods using QuEChERS-UHPLC-Q-TOF with automated identification based on MS/MS similarity algorithms[J].Food Chem,2022,395:133573.
[21] Makni Y,Diallo T,Areskoug F,et al.Optimisation and implementation of QuEChERS-based sample preparation for identification and semi-quantification of 694 targeted contaminants in honey,jam,jelly,and syrup by UHPLC-Q/ToF high-resolution mass spectrometry[J].Food Chem,2023,425:136448.
[22] Peng J,Gan JH,Liu T,et al.Development and application of a rapid screening and quantification method for multi-class herbicide residues in fishery products using UPLC-Q-Tof-MS/MS:evidence for prometryn residues in shellfish[J].Food Contr,2023,148:109672.
[23] Diallo T,Makni Y,Lerebours A,et al.Wide-scope screening of multi-class contaminants in seafood using a novel sample preparation (QuEChUP) procedure coupled with UHPLC-Q-TOF-MS:application for semi-quantitation of real seafood samples[J].Food Chem,2023,426:136572.
[24] 邓颖,林青兰,杜伟锋,等.分散固相萃取-气相色谱-四极杆-飞行时间质谱法快速测定鲜鱼中的5种酚类麻醉剂[J].食品安全质量检测学报,2021,12(21):8488-8493.
[25] Magalhães D,Freitas A,Sofia Vila Pouca A,et al.The use of ultra-high-pressure-liquid-chromatography tandem time-of-flight mass spectrometry as a confirmatory method in drug residue analysis:application to the determination of antibiotics in piglet liver[J].J Chromatogr B Analyt Technol Biomed Life Sci,2020,1153:122264.
[26] 王聪,赵晓宇,董喆,等.超高效液相色谱-四极杆串联飞行时间高分辨质谱法筛查和确证猪肉中117种兽药残留[J].食品安全质量检测学报,2021,12(9):3684-3693.
[27] 王强,王旭峰,蔡楠,等.同位素稀释/超高效液相色谱-四极杆-飞行时间质谱法测定牛蛙中50种兽药残留[J].食品安全质量检测学报,2023,14(1):187-195.
[28] 王骏,宿书芳,胡梅,等.超高效液相色谱-四极杆/飞行时间质谱筛查水果罐头中37种食品添加剂[J].食品与发酵工业,2017,43(11):212-219.
[29] 张虹艳,邱国玉,石晓峰,等.高效液相色谱-四极杆-飞行时间质谱法快速筛查保健食品中10种雄性激素类非法添加物[J].分析测试学报,2020,39(9):1085-1091.
[30] 吴婉琴,江丰,范小龙,等.高效液相色谱-四极杆-飞行时间质谱快速筛查鉴别食品中非法添加的62种中药材[J].色谱,2022,40(1):48-56.
[31] 孙健,诸艳蓉,胡青,等.超高效液相色谱-四极杆飞行时间质谱法定性筛查52种减肥类非法食品添加物[J].上海预防医学,2022,34(6):519-525.
[32] 刘杰,朱晓玲,彭青枝,等.HPLC-Q-TOF/MS测定保健食品中19种抗抑郁药物[J].食品与机械,2021,37(7):63-68.
[33] 陈世伟,陈家旭.《食品安全法》实施前后全国学生食物中毒流行特征比较分析[J].河南预防医学杂志,2019,30(9):662-665+728.
[34] 林子豪,彭名军,周庆琼,等.亲水液相色谱-串联四极杆飞行时间质谱法同时测定野生蘑菇中α-鹅膏毒肽与2种精神紊乱型毒素[J].食品科技,2023,48(1):305-309.
[35] 张美娟,陈佳,林缨,等.高分辨质谱-非信息依赖数据采集-后靶向筛查策略在不明原因食物中毒鉴定中的应用[J].分析化学,2018,46(2):157-164.
[36] Vargas-Pérez M,Domínguez I,González FJE,et al.Application of full scan gas chromatography high resolution mass spectrometry data to quantify targeted-pesticide residues and to screen for additional substances of concern in fresh-food commodities[J].J Chromatogr A,2020,1622:461118.
[37] 殷雪琰,朱佳明,堵燕钰,等.基于气相色谱-静电场轨道阱高分辨质谱法快速筛查和确证农产品中222种农药残留[J].分析测试学报,2022,41(2):172-186.
[38] 张朋杰,张宪臣,李云松,等.QuEChERS结合超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法快速测定禽畜肉中157种农药残留[J].食品安全质量检测学报,2022,13(16):5391-5400.
[39] 韩梅,侯雪,邱世婷,等.超高效液相色谱-四极杆/静电场轨道阱高分辨质谱测定豆类杂粮中53种农药残留[J].食品安全质量检测学报,2020,11(8):2437-2445.
[40] 张蓉,刘鑫,彭媛,等.改良QuEChERS结合超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法快速检测茶叶中95种除草剂残留[J].色谱,2018,36(12):1228-1237.
[41] 毕军,任君,赵云峰,等.QuEChERS-冷冻诱导液液萃取/液相色谱-高分辨质谱法测定蔬菜水果中77种农药残留[J].分析测试学报,2021,40(9):1318-1327.
[42] 岳宁,李晓慧,李敏洁,等.超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法非靶向筛查苹果中苯脲类农药[J].分析测试学报,2022,41(6):805-811.
[43] 黄合田,谢双,涂祥婷,等.Sin-QuEChERS结合超高效液相色谱-高分辨质谱法快速筛查绿茶中农药及代谢物残留[J].分析化学,2020,48(3):423-430.
[44] 于慧娟,汪洋,孔聪,等.超高效液相色谱-四极杆/静电场轨道阱高分辨质谱快速筛查鱼和虾样品中200种药物残留[J].质谱学报,2019,40(2):97-108.
[45] 郭添荣,万渝平,孙利,等.通过式固相萃取结合超高效液相色谱-四极杆/静电场轨道阱高分辨质谱快速筛查畜禽肉中108种兽药残留[J].分析化学,2022,50(2):271-289.
[46] Kaufmann A,Widmer M,Maden K,et al.High resolution mass spectrometry-based detection and quantification of β-agonists at relevant trace levels in a variety of animal-based food matrices[J].Food Addit Contam Part A Chem Anal Control Expo Risk Assess,2021,38(8):1350-1363.
[47] Dai JX,Wang Y,Lin H,et al.Residue screening and analysis of enrofloxacin and its metabolites in real aquatic products based on ultrahigh-performance liquid chromatography coupled with high resolution mass spectrometry[J].Food Chem,2023,404(Pt B):134757.
[48] 刘益锋,李蓉,刘恭源,等.高效液相色谱-四极杆/静电场轨道阱高分辨质谱法测定焙烤食品中10种添加剂[J].食品研究与开发,2019,40(19):181-186.
[49] 岑建斌,周朗君,方厚托,等.超高效液相色谱-四极杆/静电场轨道阱高分辨质谱快速测定水果中17种对羟基苯甲酸酯[J].分析测试学报,2022,41(6):843-850.
[50] 顾万江,胡黎黎,唐晓琴.超高效液相色谱-四极杆-静电场轨道阱高分辨质谱法快速筛查食品中9种工业染料[J].中国卫生检验杂志,2018,28(1):13-17.
[51] 周楠,黄姗,陈卓,等.超高效液相色谱仪-四级杆/静电轨道阱高分辨质谱法快速筛查及不同酒类中64种非法添加化合物[J].现代食品科技,2021,37(1):229-242.
[52] Chen SB,Li S,Fang KY,et al.Rapid determination of 93 banned industrial dyes in beverage,fish,cookie using solid-supported liquid-liquid extraction and ultrahigh-performance liquid chromatography quadrupole orbitrap high-resolution mass spectrometry[J].Food Chem,2022,388:132976.
[53] 罗苹,刘小红,孔芳,等.基于高分辨质谱及三重四极杆质谱的蘑菇中7种蘑菇毒素的筛查及定量分析[J].农产品质量与安全,2022(6):15-20.
[54] Zheng RJ,Huang LY,Wu YJ,et al.Simultaneous analysis of paralytic shellfish toxins and tetrodotoxins in human serum by liquid chromatography coupled to Q-Exactive high-resolution mass spectrometry[J].J Chromatogr B Analyt Technol Biomed Life Sci,2023,1215:123565.
PDF(869 KB)

Accesses

Citation

Detail

Sections
Recommended

/