Objective To analyze the development of human resources at Anhui Provincial Center for Disease Control and Prevention (Anhui CDC) from 2014 to 2023,and provide reference for the construction of talent teams in provincial disease control and prevention institutions. Methods The basic personnel information of Anhui CDC and the relevant data of China Disease Prevention and Control Information System - Basic Information System (Integrated Management Information System for Disease Control and Prevention) were collected to analyze the development and changes of human resources in Anhui CDC,including officially budgeted posts,gender composition,job categories,professional titles,and educational background composition.SPSS 21.0 was used for statistical analysis. Results From 2014 to 2023,the officially budgeted posts of the Anhui CDC increased from 273 to 373,the number of employees increased from 246 to 314,the gender ratio decreased from 1.73 to 0.95,and the proportion of health technicians increased from 86.59% to 92.99%.Among professional and technical personnel,the age composition was mainly 25 to 34 years old and 35 to 44 years old,with 25 to 34 years old accounting for 25.74% to 51.71%,and 35 to 44 years old accounting for 23.00% to 36.04%.In terms of educational background composition,from 2014 to 2023,the proportion of doctoral students increased from 2.82% to 5.48%,the proportion of master's students increased from 23.47% to 58.22%,and the proportion of undergraduate students decreased from 42.72% to 28.77%.In terms of professional title composition,the proportion of those with senior technical titles was between 6.76% and 1.11%,the proportion of those with deputy senior technical titles was between 13.55% and 23.42%,the proportion of those with intermediate technical titles was between 24.40% and 43.93%,and the proportion of those with junior and non professional titles was between 27.72% and 46.39%.In terms of job categories,public health physicians accounted for 42.42% to 51.40%,and laboratory technicians accounted for 32.39% to 37.13%. Conclusion The human resources of Anhui CDC are developing rapidly,and the personnel structure is constantly optimizing.However,there is a shortage of high-level talents,and the construction of talent team should be continuously strengthened.