Objective To understand the strains type,clinical typing,severity rate and hospitalization costs of COVID-19 cases,and provide reference basis for the prevention and treatment. Methods Relevant information to COVID-19 cases admitted to the First Affiliated Hospital of the University of Science and Technology of China,Infectious Disease Hospital Area (Hefei Infectious Disease Hospital) from November 2022 to January 2023 was collected,the proportion of strains,clinical subtypes,severity rate,treatment costs,and other related indicators were calculated.Perform statistical analysis using SPSS 26.0. Results A total of 90 COVID-19 cases were investigated,including 63 males and 27 females,aged from 27 to 96 years old.32 cases were mild from clinical classification (35.56%),47 cases were common (52.22%),and 11 cases were severe (12.22%).The distribution of strains were as follows: 57 cases (63.33%) were infected with BA.5.2.48,25 cases (27.78%) were infected with BF.7.14,and 8 cases (8.89%) were infected with other subtypes.There were 50 cases (55.56%) with underlying diseases and 40 cases (44.44%) without underlying diseases.The hospitalization cost of severe cases was higher than that of ordinary cases and mild cases (H=32.658,P<0.001),and the hospitalization cost of cases with underlying diseases was higher than those without underlying diseases (Z =5.903,P＜0.001).The severity rate of patients with underlying diseases (20.00%) was higher than that of those without underlying diseases (2.50%) (P_Fisher=0.019). Conclusion COVID-19 cases are mainly common and mild,with the main strains of BA.5.2.48 and BF.7.14.The treatment costs for severe cases and cases with underlying diseases are relatively high.